Akdemir, Ayşe S.Metin Armağan, DeryaPolat Korkmaz, ÖzgeÖzkaya, Hande M.Kadıoğlu, PınarGazioğlu, Nurperi2021-10-272021-10-272021Akdemir, A. S., Metin Armagan, D., Polat Korkmaz, O., Ozkaya, H. M., Kadioglu, P., Gazioglu, N., Tanriover, N., Dirican, A., & Ozturk, M. (2021). Association between β arrestin 2 and filamin A gene variations with medical treatment response in acromegaly patients. Minerva endocrinology, 10.23736/S2724-6507.21.03611-3. Advance online publication.https://doi.org/10.23736/S2724-6507.21.03611-3https://hdl.handle.net/20.500.12713/2191Background: Acromegaly is a disease that occurs as a result of excessive growth hormone caused by pituitary adenomas. Some acromegaly patients show resistance to somatostatin analog (SSA) treatment. Filamin-A (FLNA) and ?-arrestins are thought to play a role in the response to SSAs. We aimed to investigate the relationship between FLNA-rs782079491 and ?-arrestin-2-rs34230287 single-nucleotide polymorphisms and disease risk, as well as treatment response in patients with acromegaly in the Turkish population. Methods: The genotypes of 110 acromegaly patients and 99 controls were determined by realtime PCR. The genotype distributions were compared with clinical data on the disease. Results: There was no association between the ?-arrestin-2 gene polymorphism and the response to SSA treatment in acromegaly patients. For responder patients to SSAs, the ?-arrestin-2-rs34230287 CT+TT genotype was associated with higher microadenoma as compared with the CC genotype (p = 0.017). The FLNA polymorphism was not observed in the study group. Conclusions: We showed that there was no association between the polymorphic genotypes of FLNA and ?-arrestin-2 genes with acromegaly disease and SSAs response in the Turkish population. However, there was a relationship between ?-arrestin-2 and some of the clinical characteristics. Furthermore, the CC genotype and the C allele are risk factors associated with tumor growth rate in acromegaly patients.eninfo:eu-repo/semantics/closedAccessArticle34669321WOS:001162917400001Q310.23736/S2724-6507.21.03611-3