Salatin, SaraAlami-Milani, MitraCilvegar, HamitFereidouni, SaberMonajemzadeh, FarnazJelvehgari, Mitra2022-03-242022-03-242022Salatin S, Alami-Milani M, Cilvegar H, Fereidouni S, Maghsoodi M, Monajemzadeh F, Jelvehgari M. Development and characterization of bilayered tablets of diazepam for oral drug delivery: design, optimization and in vitro evaluation. Ther Deliv. 2022 Mar 21.https://doi.org/10.4155/tde-2021-0077https://hdl.handle.net/20.500.12713/2584Aims: The oral bioavailability of drugs can be limited by their short residence time in the gastrointestinal tract. This study was performed to design bilayered floating tablets of diazepam comprising immediate-release and controlled-release layers. Methods: The tablets were prepared using sodium starch glycolate, polyvinyl pyrrolidone, hydroxypropyl methylcellulose and microcrystalline cellulose and evaluated for their characteristics. Results: The optimized formulation was found to be buoyant for 8 h on simulated gastric fluid. Hydroxypropyl methylcellulose K4M and microcrystalline cellulose sustained the release of diazepam from the controlled-release layer. The optimized formulation exhibited an extended release period of 8 h. Discussion/conclusion: It can be concluded that bilayered tablets of diazepam may extend the residence time of the drug at the site of absorption.eninfo:eu-repo/semantics/closedAccessHPMCBilayered TabletDiazepamFloatingGastrointestinal TractOral Drug DeliveryArticle35306880WOS:0007717182000012-s2.0-85131219736N/A10.4155/tde-2021-0077N/A