Gökmen, ZelihaOnan, Mehmet ErdiDeniz, Nahide GülşahKarakaş Zeybek, DidemUlukaya, Engin2020-08-302020-08-302019Gokmen, Z., Onan, M. E., Deniz, N. G., Karakas, D., & Ulukaya, E. (2019). Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines. SYNTHETIC COMMUNICATIONS, 49(21), 3008–3016. https://doi.org/10.1080/00397911.2019.16550570039-79111532-2432https://doi.org/10.1080/00397911.2019.1655057https://hdl.handle.net/20.500.12713/5821,4-Naphthoquinones (1,4-NQ) have been reported to possess a variety of pharma-cological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic, and anticancer effects. In this study, new N- and S,S-substituted-1,4-NQ derivatives were synthesized in excellent yields and were completely characterized by spectroscopic analysis IR, NMR (H-1 and C-13), MS and microanalysis. The cytotoxic activities of 1,4-NQ derivatives were examined against to A-549, DU145, HCT-116 and MDA-MB-231 cancer cells. Among these compounds, 2-[4-(2-furoyl)piperazine-1-yl]-3-chloro-1,4-NQ 5 and 2,3-bis(cyclobuthylsulfanyl)-1,4-NQ 17 were identified as the most potent anticancer agents with cytotoxic activity against three cell lines (breast (MDA-MB-231), prostate (DU145), colorectal (HCT-116).eninfo:eu-repo/semantics/closedAccess1,4-Naphthoquinone1,4-NqHeterocyclic ThioetherCytotoxicityAnticancer AgentArticle492130083016WOS:0004840352000012-s2.0-85071323535Q310.1080/00397911.2019.1655057Q3