İşler, DeryaŞirinyıldız, FerhatEk, Rauf Onur2022-04-112022-04-112022Isler, D., Sirinyildiz, F., Ek, R. O. (2022). Effect of Ficus carica (fig) seed oil administration on GSH levels, necrosis and cast formation in myoglobinuric acute kidney injury. Cukurova Medical Journal, 47(1), 152-160.2602-3032https://doi.org/10.17826/cumj.1002023https://hdl.handle.net/20.500.12713/2630Purpose: In this study, the effect of applying different doses of Ficus carica (fig) seed oil obtained by cold pressing method on the kidney tissue and serum GSH level, as well as the formation of necrosis and cast in the experimental myoglobinuric acute kidney injury animal model created with glycerol was investigated. Materials and Methods: 32 Wistar albino male rats weighing 460-540 g were randomly divided into four groups of 8 each. Sham Control, MAKI, MAKI+FC3, MAKI+FC6. Urea and creatinine levels of the groups were analyzed by biochemical method. Tissue necrosis level was determined by histological analysis of kidney tissue sections. Results: While urea and creatinine levels increased significantly in the MAKI group compared to all groups, they were found to be lower in the high and low dose treatment groups with no significant difference between them. Tissue and serum GSH levels in the MAKI group were significantly decreased compared to all groups. In the MAKI+FC3 and MAKI+FC6 groups, an increase was detected in the tissue without dose difference, and in the serum only with high dose. The highest score in kidney tissue cast and necrosis levels were observed in the MAKI group, while significant improvements were detected in the treatment groups. Conclusion: Ficus carica(fig) seed oil, provided improvement in morphological damage with improvement in functional damage and increase in antioxidative capacity.eninfo:eu-repo/semantics/openAccessAntioxidantFicus Carica Seed OilMyoglobinuric Acute Kidney InjuryNecrosisReduced GlutathioneArticle471152160WOS:000767959700020N/A10.17826/cumj.1002023519946