Kendir, GülşenJung Bae, HoKim, JihyunJeong, YongwooJeoung Bae, HyoPark, KeontaeYang, XingquanCho, Young-JinKim, Ji-YoungJung, Seo YunKoroglu, AysegulJang, Dae SikRyu, Jong Hoon2022-08-172022-08-172022Kendir G, Bae HJ, Kim J, Jeong Y, Bae HJ, Park K, Yang X, Cho YJ, Kim JY, Jung SY, Köroğlu A, Jang DS, Ryu JH. The effects of the ethanol extract of Cordia myxa leaves on the cognitive function in mice. BMC Complement Med Ther. 2022 Aug 10;22(1):215. doi: 10.1186/s12906-022-03693-z. PMID: 35948926; PMCID: PMC9367120.2662-7671http://doi.org/10.1186/s12906-022-03693-zhttps://hdl.handle.net/20.500.12713/3096Background: Cordia myxa L. (Boraginaceae) is widely distributed in tropical regions and it's fruits, leaves and stem bark have been utilized in folk medicine for treating trypanosomiasis caused by Trypanosoma cruzi. A population-based study showed that T. cruzi infection is associated with cognitive impairments. Therefore, if C. myxa has ameliorating activities on cognitive function, it would be useful for both T. cruzi infection and cognitive impairments. Methods: In this study, we evaluated the effects of an ethanol extract of leaves of C. myxa (ELCM) on memory impairments and sensorimotor gating deficits in mice. The phosphorylation level of protein was observed by the Western blot analysis. Results: The administration of ELCM significantly attenuated scopolamine-induced cognitive dysfunction in mice, as measured by passive avoidance test and novel object recognition test. Additionally, in the acoustic startle response test, we observed that the administration of ELCM ameliorated MK-801-induced prepulse inhibition deficits. We found that these behavioral outcomes were related with increased levels of phosphorylation phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) and glycogen synthase kinase 3 beta (GSK-3?) in the cortex and extracellular signal-regulated kinase (ERK) and cAMP response element-binding protein (CREB) in the hippocampus by western blot analysis. Conclusions: These results suggest that ELCM would be a potential candidate for treating cognitive dysfunction and sensorimotor gating deficits observed in individuals with neurodegenerative diseases.eninfo:eu-repo/semantics/closedAccessAlzheimer’s DiseaseCordia MyxaERK-CREB SignalingPI3K-Akt-GSK3β SignalinRecognition MemorySensorimotor GatingArticle2219367120WOS:0008386830000032-s2.0-85135773613Q210.1186/s12906-022-03693-zQ1