Özmen, Mehmet MahirGüldoğan, Cem EmirGündoğdu, Emre2020-08-302020-08-302020Ozmen, M. M., Guldogan, C. E., & Gundogdu, E. (2020). Changes in HOMA-IR Index Levels After Bariatric Surgery: Comparison of Single Anastomosis Duodenal Switch-proximal approach (SADS-p) and One Anastomosis Gastric Bypass-Mini Gastric Bypass (OAGB-MGB). International Journal of Surgery.1743-9191https://doi.org/10.1016/j.ijsu.2020.04.008https://hdl.handle.net/20.500.12713/282Background: Bariatric surgery plays a major role in ameliorating metabolic abnormalities of type 2 diabetes (T2DM). The aim of this study was to evaluate the early effects of “Single Anastomosis Duodenal Switch-proximal approach” (SADS-p) and “One Anastomosis Gastric Bypass-Mini Gastric Bypass (OAGB-MGB) on the “homeostasis model assessment of insulin resistance” (HOMA-IR) index levels in morbidly obese patients with T2DM. Methods: In this retrospective 3-year trial, outcomes of SADS-p and OAGB-MGB patients were compared considering the changes in HOMA-IR index levels. All bariatric procedures were performed by a single primary surgeon recognized as a surgeon of excellence by IFSO-EC with the assistance of one or two additional attending surgeons. SADS-p was performed on 60(10 males) patients, and 200(27 males) patients underwent OAGB-MGB. Forty-six patients (78%) in the SADS-p group and 125 (63%) in the OAGB-MGB group had T2DM. Patients were evaluated before surgery and 1,3,9,12 months after surgery. Results: In both groups, the HOMA-IR index levels decreased significantly after surgery (p < 0.05), and both procedures markedly improved glycemic control. In the SADS-p group the HOMA-IR index levels significantly decreased from 6.2 to 1.4 after the 12th month of surgery (p < 0.05), in OAGB-MGB group HOMA-IR index levels significantly decreased from 5,9 to 1.7 after the 12th month of surgery (p < 0.05). Conclusion: Both procedures are promising operations which offer excellent control on weight, HOMA-IR index and diabetes. © 2020 IJS Publishing Group Ltdeninfo:eu-repo/semantics/closedAccessBariatric SurgeryDiabetesHoma-IrInsulinMetabolic SurgeryMorbid ObesityOagb-MgbOne Anastomosis Gastric Bypass-Mini Gastric BypassRobotic Gastric BypassSingle Anastomosis Duodenal Switch-Proximal ApproachType 2 DiabetesWeight LossArticle78364132305534WOS:0005392599000162-s2.0-85083528782Q110.1016/j.ijsu.2020.04.008Q1