Yilmaz-Aykut, DilaraTorkay, GulsahKasgoz, AlperShin, Su RyonBal-Ozturk, AycaDeligoz, Huseyin2024-05-192024-05-1920231552-49731552-4981https://doi.org10.1002/jbm.b.35295https://hdl.handle.net/20.500.12713/5043Injectable hydrogels based on natural polymers have shown great potential for various tissue engineering applications, such as wound healing. However, poor mechanical properties and weak self-healing ability are still major challenges. In this work, we introduce a host-guest (HG) supramolecular interaction between acrylate-beta-cyclodextrin (Ac-beta-CD) conjugated on methacrylated kappa-carrageenan (MA-kappa-CA) and aromatic residues on gelatin to provide self-healing characteristics. We synthesize an MA-kappa-CA to conjugate Ac-beta-CD and fabricate dual crosslinked hybrid hydrogels with gelatin to mimic the native extracellular matrix (ECM). The dual crosslinking occurs on the MA-kappa-CA backbone through the addition of KCl and photocrosslinking process, which enhances mechanical strength and stability. The hybrid hydrogels exhibit shear-thinning, self-healing, and injectable behavior, which apply easily under a minimally invasive manner and contribute to shear stress during the injection. Invitro studies indicate enhanced cell viability. Furthermore, scratch assays are performed to examine cell migration and cell-cell interaction. It is envisioned that the combination of self-healing and injectable dual crosslinked hybrid hydrogels with HG interactions display a promising and functional biomaterial platform for wound healing applications.eninfo:eu-repo/semantics/closedAccessDual CrosslinkingGelatinKappa-CarrageenanHost-Guest InteractionSelf-Healing HydrogelWound HealingArticle111111921193737350561WOS:0010198318000012-s2.0-85162861970N/A10.1002/jbm.b.35295Q2