Varzandeh, MohammadMohammadinejad, RezaEsmaeilzadeh-Salestani, KeyvanDehshahri, AliZarrabi, AliAghaei-Afshar, Abbas2021-11-152021-11-152021Varzandeh, M., Mohammadinejad, R., Esmaeilzadeh-Salestani, K., Dehshahri, A., Zarrabi, A., & Aghaei-Afshar, A. (2021). Photodynamic therapy for leishmaniasis: recent advances and future trends. Photodiagnosis and photodynamic therapy, 102609. Advance online publication.https://doi.org/10.1016/j.pdpdt.2021.102609https://hdl.handle.net/20.500.12713/2232Leishmaniasis has infected more than 12 million people worldwide. The neglected tropical disease causing 20,000-30,000 deaths per year determined as a global health problem. The emergence of resistant parasites and serious side effects of the conventional therapies has led to the search for less toxic and non-invasive alternative treatments. Photodynamic therapy is a promising therapeutic strategy to produce reactive oxygen species for the treatment of leishmaniasis. In this regard, natural and synthetic photosensitizers such as curcumin, hypericin, 5-aminolevulinic acid, phthalocyanines, phenothiazines, porphyrins, chlorins and nanoparticles have been applied. In this review, the recent advances on using photodynamic therapy for treating Leishmania species have been reviewed.eninfo:eu-repo/semantics/closedAccessLeishmaniaPhotodynamic TherapyLeishmaniasisNanoparticlesParasitesPhotosensitizersReview Article3634728420WOS:0007197807000072-s2.0-85118891276Q310.1016/j.pdpdt.2021.102609N/A