Alawfi, Bader SaleemKhan, Naveed AhmedLloyd, DavidSiddiqui, Ruqaiyyah2025-04-182025-04-182024Alawfi, B. S., Khan, N. A., Lloyd, D., & Siddiqui, R. (2024). Acanthamoeba keratitis: new hopes for potential interventions for a curable but often refractory disease. Expert Review of Ophthalmology, (just-accepted).1746-98991746-9902http://dx.doi.org/10.1080/17469899.2024.2370881https://hdl.handle.net/20.500.12713/6866IntroductionOften associated with contact lens wear, Acanthamoeba keratitis is an extremely painful blinding infection that has remained significant despite advances in drug discovery and chemotherapies. Current treatment is intricate and demands early diagnosis, aggressive and prolonged application, and may result in infection recurrence. The latter is due to the ability of the parasite to undergo cellular differentiation and transform into a resistant cyst form or infective trophozoite form. Areas coveredHere, we present a review of our current understanding of emerging therapies and priorities tackling Acanthamoeba keratitis. Literature searches were carried out using bibliographic databases and results sifted and reviewed to present recent findings, challenges and novel opportunities in the development of therapeutic interventions and/or preventative measures against Acanthamoeba keratitis. Expert opinionNanomedicine-based theranostics to combine diagnosis and treatment of Acanthamoeba keratitis offer remarkable opportunity in the development of clinical applications in the management of Acanthamoeba keratitis.eninfo:eu-repo/semantics/closedAccessAcanthamoebaSight-Threatening AmoebaEye InfectionFree-Living AmoebaeEmerging TherapiesOther194271280WOS:0012530853000012-s2.0-85196748071N/A10.1080/17469899.2024.2370881Q3