Olgun, Abdullah2020-08-302020-08-302019Olgun, A. (2019). Selective targeting of signet ring cell adenocarcinomas. MEDICAL HYPOTHESES, 133. https://doi.org/10.1016/j.mehy.2019.1093800306-98771532-2777https://doi.org/10.1016/j.mehy.2019.109380https://hdl.handle.net/20.500.12713/512Many epithelial tumors, especially signet-ring cell adenocarcinomas, produce huge amounts of mucin glycoproteins that fill cytoplasm and push nucleus to the periphery, giving a signet ring like structure to the cell. Mucin proteins are very rich of l-threonine which is essential in humans. L-threonine content can reach up to 35% of total amino acid composition of some mucin proteins. Therefore l-threonine can be the Achilles heel of signet ring cell adenocarcinomas which are one of the most malignant and agressive cancers. A modified bioisoster of l-threonine, 4-fluoro l-threonine (its fluorine can be radioactive or not), can be used to selectively kill signet ring cancer cells without harming normal cells or for diagnostic purposes.eninfo:eu-repo/semantics/closedAccessSignet-Ring Cell CancerMucin Proteins4-Fluoro L-ThreonineSystemic RadiotherapyArticle13331454636WOS:0005003605000012-s2.0-85071099394Q410.1016/j.mehy.2019.109380Q2