Cevatemre, B.Dere, E.Ulukaya, Engin2021-11-192021-11-192018Cevatemre, B., Dere, E., & Ulukaya, E. (2018). PO-197 A possible link between the mitochondrial gatekeeper pyruvate dehydrogenase enzyme complex and EMT. ESMO Open, 3, A97.2059-7029https://doi.org/10.1136/esmoopen-2018-EACR25.233https://hdl.handle.net/20.500.12713/2264Introduction In recent years, mitochondria have attracted much attention in metastatic cancer research. The first finding of the importance of mitochondria in cancer was reported by Otto Warburg in 1920. In the following years,it was found that cancer is closely related to mitochondrial characteristics such as glucose metabolism and chemoresistance. In this context,epithelial mesenchymal transition (EMT), due to its potential of being a molecular marker for tumour metastasis, clarification of this process is essential. Although increments have been made in metastatic cancer research,there are no studies showing the relationship between pyruvate dehydrogenase enzyme complex (PDH) and EMT.eninfo:eu-repo/semantics/closedAccessOther3Supplement 210.1136/esmoopen-2018-EACR25.233