Erdem, BakiAşıcıoğlu, OsmanSeyhan, Niyazi AlperPeker, NuriÜlker, VolkanAkbayır, Özgür2020-08-302020-08-302018Erdem, B., Aşıcıoğlu, O., Seyhan, N. A., Peker, N., Ülker, V., & Akbayır, Ö. (2018). Can concurrent high-risk endometrial carcinoma occur with atypical endometrial hyperplasia?. International Journal of Surgery, 53, 350-353.1743-91911743-9159https://doi.org/10.1016/j.ijsu.2018.04.019https://hdl.handle.net/20.500.12713/792Background: This study investigated the frequency of high-risk cancer types in hysterectomy material obtained from patients who were diagnosed with atypical endometrial hyperplasia (AEH) by endometrial sampling. Materials and methods: A total of 227 patients with AEH were retrospectively included in the study. Hysterectomy material was examined as both perioperative frozen section (FS) and paraffin-embedded permanent section (PS). Grade III tumors, grade II tumors larger than 2 cm, over 50% myometrial invasion, cervical involvement, and serous or clear cell histology were considered high-risk. Results: In final pathology, 57 (25.1%) patients had endometrial cancer and 7 (3%) patients had high-risk cancer. Overall analysis of FS/PS agreement yielded a Cohen's Kappa (K) coefficient of 0.420 (moderate agreement). There was moderate (K=0.526) agreement between FS and PS in detecting tumor grade, and good agreement (K=0.653) in evaluation of myometrial invasion. Conclusion: High-risk endometrial cancer can coexist with AEH. It should be remembered that despite pre-operative and FS examinations, these high-risk tumors can be overlooked until final pathology.eninfo:eu-repo/semantics/openAccessAtypical Endometrial HyperplasiaEndometrial CancerFrozen SectionArticle5335035329665453WOS:0004326544000542-s2.0-85045706824Q110.1016/j.ijsu.2018.04.019Q1