Alparslan, LeventAkkurt, BarbarosAgar, Soykan2025-04-182025-04-1815 Mayıs 2Agar, S., Akkurt, B., & Alparslan, L. (2024). De novo Drug Design to Suppress Coronavirus RNA-Glycoprotein via PNA-Calcitonin. Journal of the Turkish Chemical Society Section A: Chemistry, 11(2), 623-632.https://hdl.handle.net/20.500.12713/6802De novo drug design has been studied utilizing the organic chemical structures of Salmon Calcitonin 9 - 19 and Peptide Nucleic Acid (PNA) to suppress Coronavirus Ribonucleic Acid (RNA)-Glycoprotein complex. PNA has a polyamide backbone and Thymine pendant groups to selectively bind and inhibit Adenine domains of the RNA-Glycoprotein complex. While doing so, molecular docking and molecular dynamics studies revealed that there is great inhibition docking energy (-12.1 kcal/mol) with significantly good inhibition constant (124.1 µM) values confirming the efficient nucleotide-specific silencing of Coronavirus RNA-Glycoprotein complex.eninfo:eu-repo/semantics/openAccessSalmon CalcitoninCoronavirus RNACoronavirus GlycoproteinMolecular DockingMolecular DynamicsHydrogen Contact MappingArticle11262363210.18596/jotcsa.1406290