Üçbilek, EnverYıldırım, Abdullah EmreEllik, ZeynepTuran, İlkerHaktanıyan, BüşraKaratay, Eylem2025-06-032025-06-032024Üçbilek, E., Yıldırım, A. E., Ellik, Z., Turan, İ., Haktanıyan, B., Orucu, B., ... & Idilman, R. (2024). Changing trends in the etiology of cirrhosis in Türkiye: a multicenter nationwide study. The Turkish Journal of Gastroenterology, 35(10), 772.2148-5607http://dx.doi.org/10.5152/tjg.2024.23572https://hdl.handle.net/20.500.12713/7286Background/Aims: The aim of our study was to investigate the underlying causes behind the etiology of cirrhosis in T & uuml;rkiye.Materials and Methods: The study was comprised of patients with cirrhosis located in the gastroenterology clinics of 28 centers in T & uuml;rkiye between January 2000 and June 2021. Results: The study group consisted of 4953 cirrhotic patients (median age: 62.2 years, male / female: 58% / 42%). Among the patients, 39% of the patients were compensated, and 61% were decompensated. Furthermore, 47.5% had Child-Pugh class A, 38% had Child-Pugh class B, and 14.5% had Child-Pugh class C. The most frequent complaints were abdominal bloating (28%). Ascites (54.2%) was the most common manifestation of decompensation. The median Child-Pugh and MELD-Na scores were 7.0 and 10.0, respectively. The most common cause of cirrhosis was chronic viral hepatitis (43%), followed by cryptogenic cirrhosis (CC) (19%), metabolic dysfunc-tion-associated steatotic liver disease (MASLD)-related cirrhosis (13%), and alcohol-related cirrhosis (11%). Among the 950 patients with CC, 416 had metabolic abnormalities. If these 416 CC patients with metabolic abnormalities were categorized as having MASLD-related cirrhosis, the proportion of MASLD-related cirrhosis increased to 21%. Thirteen percent of the patients were diagnosed with HCC, while 4% had extrahepatic malignancy. Female breast cancer (18%) and colorectal cancer (18%) were the most frequent extra-hepatic malignancies. Conclusion: Viral hepatitis remains the main cause of cirrhosis in T & uuml;rkiye. However, its prevalence seems to be declining, whereas the prevalence of steatotic liver disease-related cirrhosis is increasingeninfo:eu-repo/semantics/openAccessCirrhosisEtiologyHepatocellular CarcinomaMetabolic Dysfunction-Associated Steatotic Liver DiseaseViral HepatitisArticle3510772777WOS:0013442002000032-s2.0-85205994317Q410.5152/tjg.2024.23572Q3