Özler, SibelÖztaş, EfserGümüş Güler, BaşakErel, ÖzcanÇağlar, Ali TurhanErgin, MerveDanışman, Nuri2020-08-302020-08-302020Ozler, S., Oztas, E., Guler, B. G., Erel, O., Caglar, A. T., Ergin, M., & Danisman, N. (2020). Dynamic thiol/disulfide homeostasis in predicting adverse neonatal outcomes in fetal growth restriction. Fetal and Pediatric Pathology, 39(2), 132-144.1551-38151551-3823https://doi.org/10.1080/15513815.2019.1644686https://hdl.handle.net/20.500.12713/591Aim: The main aim of this study was to investigate thiol/disulfide homeostasis associated with fetal growth restriction (FGR) and to evaluate whether alterations are predictive for adverse neonatal outcomes. Methods: 273 pregnant women (77 with FGR and 196 with normal fetal growth) were enrolled in this prospective case-control study. Results: Native thiol and total thiol were decreased in FGR compared to the control group (p < .001; p < .001). Decreased levels of maternal serum native and total thiol were significantly associated with adverse neonatal outcomes in FGR (OR: 0.983, 95% CI 0.976-0.991, p < .001; OR: 0.983, 95% CI 0.976-0.991, p < .001). Decreased maternal serum total thiol levels were the only significantly associated risk factor with adverse neonatal outcomes in FGR (OR: 0.981, 95% CI 0.963-1.000, p = .046). Conclusion: The decrease in the antioxidants of thiol/disulfide mechanism may be related to the development of both FGR and adverse neonatal outcome in FGR.eninfo:eu-repo/semantics/closedAccessFetal Growth RestrictionDynamic Thiol Disulfide HomeostasisAdverse Neonatal OutcomesArticle39213214431362586WOS:0004794023000012-s2.0-85075514866Q410.1080/15513815.2019.1644686Q3