Serin, IstemiDogu, Mehmet HilmiEkinci, OmerCagliyan, Gulsum AkgunBasturk, AbdulkadirAras, Merih ReisDemircioglu, Sinan2024-05-192024-05-1920232619-97932148-094Xhttps://doi.org10.4274/imj.galenos.2023.66742https://search.trdizin.gov.tr/yayin/detay/1179468https://hdl.handle.net/20.500.12713/5477Introduction: Ruxolitinib is a small -molecule inhibitor of the JAK1/2 pathway. This study aimed to reveal the results and side-effect profile of the use of ruxolitinib as a treatment option in polycythemia vera (PV). Methods: A total of 34 patients with PV from 18 different centers were included in the study. The evaluation of the response under treatment with ruxolitinib was determined as a reduction in spleen volume (splenomegaly size: >= 35%) by imaging and control of hematocrit levels (<= 45%) compared to baseline. Results: While the number of patients in which a reduction in spleen volume and hematocrit control was achieved was 19 (55.9%) at 3 months of treatment, it was 21 (61.8%) at 6 months. Additionally, while the number of side effects was negatively correlated with the reduction in spleen volume (Spearman's rho: -0.365, p=0.034), a decrease in the hematocrit level was positively correlated (Spearman's rho: 0.75, p=0.029). Those without a reduction in spleen volume experienced more constipation (chi-square: 5.988, Fisher's exact test: p=0.033). Conclusion: This study shed light on the use of ruxolitinib in PV and the importance of splenomegaly on studies planned with larger patient groups.eninfo:eu-repo/semantics/openAccessPolycythemia VeraRuxolitinibReal-Life DataResponseSide EffectArticle242120125WOS:001000376900004N/A10.4274/imj.galenos.2023.667421179468