Bochani, ShayestehZarepour, AtefehKalantari-Hesari, AliHaghi, FakhriShahbazi, Mohammad-AliZarrabi, AliTaheri, Sophia2024-05-192024-05-1920232050-750X2050-7518https://doi.org10.1039/d3tb01278fhttps://hdl.handle.net/20.500.12713/5767Bacterial infection is one of the main challenges of wound healing. It imposes financial and healthcare costs. The emergence of antibiotic-resistant bacteria has increased concerns about this challenge, and made finding alternative solutions a crucial aim. We created a new, antibacterial, multifunctional hydrogel with synergistic chemodynamic and photothermal features for wound-healing applications. We fabricated a chitosan (CT)-based hydrogel containing tannic acid (TA), Fe, and MnO2 nanosheets (CT-TA-Fe-MnO2) via a simple method and characterized it. The antibacterial features (resulting from the production of reactive oxygen species within bacterial cells) and healing ability (via anti-inflammatory and hemostatic features) of the hydrogel were confirmed in vitro. In vivo results revealed the effectiveness of the CT-TA-Fe-MnO2 hydrogel in decreasing the hemostatic time, improving anti-inflammatory effects, and promoting wound healing during 14 days by enhancing the deposition and maturation of collagen fibers without affecting the vital organs. The fabricated CT-TA-Fe-MnO2 hydrogel could be a promising candidate with antibacterial and anti-inflammatory activities suitable for wound-healing applications.eninfo:eu-repo/semantics/closedAccess[No Keywords]Article37545169WOS:0010431491000012-s2.0-85168596568N/A10.1039/d3tb01278fQ1