Trawally, MuhammedYilmaz, Fatima NurOzbek Celik, BernaAkdemir, AtillaGuzel Akdemir, Ozlen2024-05-192024-05-1920242630-6344https://doi.org10.29228/jrp.689https://hdl.handle.net/20.500.12713/5456Human parainfluenza viruses (HPIVs) are responsible for a wide range of respiratory infections in humans, particularly in children, the elderly, and immunocompromised individuals. This paper presents a study regarding the antiviral activity of a series of 3-phenyl-5-sulfamoyl-N-(7/8/9-(non)substituted-3-oxo-1-thia-4- azaspiro[4.4]non/[4.5]dec-4-yl)-1H-indole-2-carboxamide derivatives against HPIV-2. Our findings suggest the compounds displayed low potency against HPIV-2. Compounds 4 and 8 exhibited the most potent antiviral effects with inhibition of 95.46 and 90.90 % at 10 mg/mL, respectively. Molecular modeling studies were conducted on hemagglutinin-neuraminidase, a crucial druggable target for HPIV, to predict the binding modes of the compounds.eninfo:eu-repo/semantics/openAccessParainfluenza VirusHpiv-2IndoleThiazolidinoneHemagglutinin-NeuraminidaseMolecular DockingArticle281213224WOS:0011672977000132-s2.0-85185505017N/A10.29228/jrp.689Q3