Kadıhasanoğlu, MustafaAydın, MustafaTaşkıran, MehmetKendirci, Muammer2020-08-302020-08-302019Kadihasanoglu, M., Aydin, M., Taskiran, M., & Kendirci, M. (2019). The Effect of Intravesical Prostatic Protrusion in Patients with Benign Prostatic Hyperplasia: Controlled, Clinical Study. Urologia internationalis, 103(2), 180-186.0042-11381423-0399https://doi.org/10.1159/000499437https://hdl.handle.net/20.500.12713/689Background: Although prostate cancer releases more prostate-specific antigen (PSA) per unit of prostate volume (PV), data are limited regarding the association between intravesical prostatic protrusion (IPP) and the PSA level. Objectives: The study aim was to evaluate the IPP effect in patients with benign prostatic hyperplasia. Method: This study included patients with (n = 119) and without (n = 121) IPP. The age, International Prostate Symptom Score (IPSS), PSA level, maximum and average flow rates, PV, hematuria, urinary retention, and post-void residual (PVR) volume were compared between the 2 groups. Results: The mean ages were similar between the 2 groups (66.56 +/- 8.67 and 66.92 +/- 8.7 years, respectively, p = 0.747), and there were no statistically significant differences in the IPSS, maximum and average flow rates, hematuria, PVR volume, and urinary retention means (p > 0.05). However, the IPP patients had lower total PSA (tPSA) and free PSA (fPSA) levels than those without IPP (3.55 [4.18] vs. 5.26 [5.24] ng/mL, p = 0.013 and 0.7 [1.09] vs. 1.05 [1.23] ng/mL, p = 0.029, respectively). Moreover, there were strong positive correlations between the IPP grade and the tPSA and fPSA levels (r = 0.262, p = 0.001 and r = 0.254, p = 0.002 respectively). Conclusions: This study demonstrated that IPP results in a decreased PSA level, even with a higher PV. (C) 2019 S. Karger AG, Baseleninfo:eu-repo/semantics/closedAccessBenign Prostatic HyperplasiaProstate Specific AntigenProstateUltrasoundUroflowmetryIntravesical Prostatic ProtrusionArticle103218018631039569WOS:0004814590000082-s2.0-85065583133Q310.1159/000499437Q2