Yaşayan, GökçenAlarçin, EmineAvcı Adalı, Meltemİpek, Tuba ÇanakNejati, OmidÖzcan Bülbül, EceKarslı, SeherÖztürk, Ayça BalMostafavi, Ebrahim2025-04-182025-04-182024Yaşayan, G., Alarcin, E., Avci-Adali, M., Ipek, T. C., Nejati, O., Özcan-Bülbül, E., ... & Mostafavi, E. (2024). Biocompatibility and toxicity challenges of nanomaterials. In Functionalized Nanomaterials for Cancer Research (pp. 603-631). Academic Press.978-044315518-5, 978-044315519-2https://hdl.handle.net/20.500.12713/6532Cancer is one of the most challenging diseases to treat and is one of the leading reasons for human death worldwide. In cancer research, nanomaterials are evaluated as an encouraging system due to their promising properties, consisting of nanoscale sizes and chemical and physical configurations that can be functionalized for the final application. Although much effort has been extended to efficient cancer research, the biocompatibility and toxicity of nanomaterials remain the main challenges. Cellular reactions are correlated with the physicochemical characteristics of nanomaterials. There are several structural parameters on which nanotoxicological reactions depend, such as size, charge, surface chemistry, and morphology. Notably, understanding the challenges is highly desirable to take full advantage of the benefits provided by nanomaterials. Therefore, this chapter covers the latest biocompatibility and toxicity findings from cancer studies using nanomaterials. Moreover, this chapter demonstrates the experiences learned and challenges faced by a group of leading scientists in this discipline. Also, it covers the physical, chemical, and biological strategies to make nanomaterials more biocompatible and nontoxic.eninfo:eu-repo/semantics/closedAccessBiocompatibilityCancer ResearchNanomaterialToxicityBook Chapter6036312-s2.0-8519334349710.1016/B978-0-443-15518-5.00019-7