Türkkan, GörkemBilici, NazlıSertel, HüseyinKeşküş, YavuzAlkaya, SercanÖzkırım, MügeFayda, Merdan2022-09-062022-09-062022Turkkan G, Bilici N, Sertel H, Keskus Y, Alkaya S, Tavli B, Ozkirim M, Fayda M. Clinical utility of a 1.5 T magnetic resonance imaging-guided linear accelerator during conventionally fractionated and hypofractionated prostate cancer radiotherapy. Front Oncol. 2022 Aug 16;12:909402. doi: 10.3389/fonc.2022.909402. PMID: 36052268; PMCID: PMC9424496.2234-943Xhttp://doi.org/10.3389/fonc.2022.909402https://hdl.handle.net/20.500.12713/3122Purpose: To report our initial experience with 1.5 T magnetic resonance imaging (MRI) linear accelerator (LINAC) in prostate cancer radiotherapy in terms of its use in a radiation oncology clinic. Methods: The medical records of 14 prostate cancer patients treated with MRI-guided radiotherapy were retrospectively evaluated. The fraction time, adapt-to-position (ATP):adapt-to-shape (ATS) usage rate, machine-associated treatment interruption rate, median gamma pass rate, the percentage of planning target volume receiving at least 95% of the prescription dose coverage value of each ATS fraction, the effect of the learning curve on the fraction time and radiation-related acute gastrointestinal and genitourinary toxicities were evaluated. Results: Fourteen patients have completed their treatment receiving a total of 375 fractions. Six patients (42%) were treated with the moderately hypofractionated regimen, five patients (36%) with conventionally fractionated, and three patients (22%) with the ultra-hypofractionated radiotherapy regimens. The ATP : ATS usage ratio was 3:372. The median fraction time was 46 min (range, 24-81 min). For the 3%/3 mm criterion, median gamma pass rate was 99.4% (range, 94.6-100%). Machine-related treatment interruptions were observed in 11 (2.9%) of 375 fractions, but this interruption rate decreased from 4.1% to 0.8%, after an upgrade. Three patients (22%) had gastrointestinal and five patients (36%) had genitourinary toxicity. No ?grade 3 toxicity was observed. Conclusion: 1.5 T MRI-LINAC device could be used as a conventional LINAC device, when the conditions of the radiotherapy center are appropriate. MRI-guided prostate radiotherapy is safe and feasible, and high-quality studies with a larger number of patients and long-term results are needed to better evaluate this new technology.eninfo:eu-repo/semantics/openAccessMRI-LINACMRI-Guided RadiotherapyAdaptive RadiotherapyFractionated RadiotherapyProstate CancerArticle16129424496WOS:0008473265000012-s2.0-85137057116Q210.3389/fonc.2022.909402Q2