Hanay, Saltuk BugraFallah, AliSenturk, EfsunYetim, ZelihaAfghah, FerdowsYılmaz, HülyaCulha, MustafaKoc, Bahattin2021-12-272021-12-272021Hanay, S. B., Fallah, A., Senturk, E., Yetim, Z., Afghah, F., Yilmaz, H., ... & Varma, R. S. (2021). Exploiting Urazole’s Acidity for Fabrication of Hydrogels and Ion-Exchange Materials. Gels, 7(4), 261.2310-2861https://doi.org/10.3390/gels7040261https://hdl.handle.net/20.500.12713/2356In this study, the acidity of urazole (pKa 5–6) was exploited to fabricate a hydrogel in two simple and scalable steps. Commercially available poly(hexamethylene)diisocyanate was used as a precursor to synthesize an urazole containing gel. The formation of urazole was confirmed by FT-IR and1 H-NMR spectroscopy. The hydrogel was characterized by microscopy imaging as well as spectroscopic and thermo-gravimetric analyses. Mechanical analysis and cell viability tests were performed for its initial biocompatibility evaluation. The prepared hydrogel is a highly porous hydrogel with a Young’s modulus of 0.91 MPa, has a swelling ratio of 87%, and is capable of exchanging ions in a medium. Finally, a general strategy was demonstrated to embed urazole groups directly into a crosslinked material.eninfo:eu-repo/semantics/openAccessBiomaterialsHydrogelsIon-ExchangePorous GelsUrazoleArticle7434940320WOS:0007376201000012-s2.0-85121419582Q110.3390/gels7040261Q2