Yılmaz Yeğit, CansuErgenekon, PınarYanaz, MürüvvetÖztürk Akar, NezafetToktaş Yavuz, FatmaMolla Kafi, HaleÇollak, AbdülhamitBal, NilüferGedik Toker, ÖzgeMeral, ÖzgeAtaş, AhmetÇetin Kara, HalideKarasu, Nesibe2025-04-182025-04-182025Yilmaz Yegit, C., Ergenekon, P., Yanaz, M., Ozturk Akar, N., Toktas Yavuz, F., Molla Kafi, H., ... & Karadag, B. (2025). The Association between Aminoglycoside Exposure and Ototoxicity in Children with Cystic Fibrosis. Respiration, 104(1), 48-57.00257931http://dx.doi.org/10.1159/000541447https://hdl.handle.net/20.500.12713/6963Introduction: Pulmonary exacerbations increase the requirement of aminoglycoside (AG) antibiotics in people with cystic fibrosis (pwCF). Several studies have shown that AGs have a cumulative effect on ototoxicity. We aimed to investigate the relationship between AG exposure and ototoxicity by using 3 different methods in patients with CF. Materials/Methods: The multicenter study included 121 pwCF aged between 5 and 18 years with a history of parenteral AG exposure. Standard pure-tone audiometry, extended high-frequency pure-tone audiometry (EHF-PTA), and distortion-product otoacoustic emissions (DPOAE) tests were performed. Mitochondrial mutation analysis for m1555G>A was performed in 61 patients. Results: Median age was 12.85 years and 52.1% (n = 63) were male. 18.2% (n = 22) of the patients had received parenteral AGs more than 5 courses/lifetime. Ototoxicity was detected in at least one of the tests in 56.2% (n = 68) of the patients. Only 10.7% (n = 13) of the patients had reported a symptom indicating ototoxicity. 30.3% (n = 30) of the patients had ototoxicity in the low exposure group, while it was 45.5% (n = 10) in the high exposure group according to EHF-PTA (p > 0.05). Median number of parenteral amikacin courses was significantly higher in the ototoxic group (2 [1.25-5.75] vs. 2 [1-3]; p = 0.045). No m1555A>G mutation was detected in 61 patients who screened for mitochondrial mutation analysis. Conclusion: As AG ototoxicity occurs primarily at high frequencies, EHF-PTA is important in early detecting ototoxicity. EHF-PTA and DPOAE detected ototoxicity in some patients with normal PTA results. All pwCF with a history of AG exposure should be evaluated for hearing loss since symptoms may only be noticed in the late period. © 2024 S. Karger AG, Basel.eninfo:eu-repo/semantics/closedAccessAminoglycosidesCystic FibrosisOtotoxicityArticle10414857392992242-s2.0-8520855549310.1159/000541447Q1