İstinye Üniversitesi Kurumsal Akademik Arşivi
DSpace@İstinye, İstinye Üniversitesi tarafından doğrudan ve dolaylı olarak yayınlanan; kitap, makale, tez, bildiri, rapor, araştırma verisi gibi tüm akademik kaynakları uluslararası standartlarda dijital ortamda depolar, Üniversitenin akademik performansını izlemeye aracılık eder, kaynakları uzun süreli saklar ve telif haklarına uygun olarak Açık Erişime sunar.
Güncel Gönderiler
Characterization of different orchid species and rheological properties of orchids solutions
(Academic press, 2024) Develioğlu-Arslan, Ayşen; Sağdıç, Osman; Tekin-Çakmak, Zeynep H.; Karasu, Salih; Kayacan-Çakmakoğlu, Selma; Yaman, Mustafa
This study investigated the physicochemical, bioactive, and rheological properties of salep obtained from ten different wild orchids collected from different regions of Turkey ( Anacamptis pyramidalis, Orchis isaura, Anacamptis palustris subsp. palustris, Orchis morio, Serapias vomeracea subsp. artemisiae, Orchis italica, Ophrys mammosa, Orchis sancta, Dactylorhiza euxina, Ranunculus ficaria subsp. calthifolius, and commercial salep). Firstly, the salep samples were ground and their color, pH, bioactive components, and FTIR spectrum were determined. The color and pH properties of salep differed due to the different species (p <= 0.05). Two strong peaks were observed at 1618 and 1422 cm-1 due to asymmetric and symmetric stretching of the ester groups in salep glucomannan. According to salep species, there was a significant difference in the TPC (total phenolic content), % DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging activity, and CUPRAC values (p <= 0.05), which were 5.29-26.84 mg GAE/g, 5.02-12.2%, and 0.81-3.82 mg TE/g, respectively. The FTIR findings revealed that the spectrum peaks did not change between commercial salep and other salep species. In the second part of the study, we prepared 1%, 2%, and 3% aqueous solutions of salep and examined their flow behavior, dynamic rheological properties, and 3-ITT (3-Time Interval Thixotropic Test) rheological behavior. A significant difference was observed between the values (p <= 0.05). All salep solutions had a flow behavior index (n) value below 1, indicating that all samples exhibited shear-thinning behavior. The consistency coefficient (K) value significantly changed (p <= 0.05) and was determined to be 0.003-2.91 Pa.sn,0.003-28.81 Pa.sn,and 0.017-94.134 Pa.sn at salep concentrations of 1%, 2%, and 3%, respectively. Salep is a preferred stabilizer due to its functional properties, bioactive components, and polysaccharide structure. As a result, when the rheological properties of salep samples are evaluated, it is shown that especially Anacamptis pyramidalis, Orchis morio, Orchis sancta species can be used as stabilizers in the food industry.
Characterization of a copper matrix composite reinforced with nano/submicron-sized boron fabricated via spark plasma sintering
(Elsevier ltd, 2024) Şahin, Rabia Tuğçe; Atak, Ömer Faruk; Burçak, Arda Baran; Jahangiri, Hadi; Motallebzadeh, Amir; Aydemir, Umut; Mohagheghi, Samira
The addition of various reinforcing phases can improve the mechanical properties of copper. This study investigates the enhancement of the mechanical properties of copper by adding boron, focusing on overcoming the challenges associated with the homogeneous distribution of submicron/nanoscale secondary phases in metal matrix composites. Employing a combination of mechanical alloying and spark plasma sintering, a copper-boron composite containing 3 wt% boron was prepared. Scanning electron microscopy equipped with an electron backscatter diffraction detector and energy-dispersive X-ray spectroscopy was utilized to characterize the structure of the sintered samples and mechanically alloyed powder. A two-phase structure containing nano/submicron-sized boron distributed uniformly in the copper matrix was formed in the sintered sample. Instrumented micro-indentation tests were performed to characterize the mechanical behavior of the samples. The sintered composite sample exhibits significantly higher hardness than the sintered copper. The enhanced mechanical performance of the composite is primarily attributed to grain boundary strengthening and microstructural refinement, where nano/submicron-sized boron particles prevent grain growth and refine the microstructure, enhancing hardness and strength. Additionally, dispersion strengthening from hard boron particles and the presence of a high density of twin boundaries within the copper matrix increase resistance to dislocation motion and deformation, and further improving the material's mechanical properties. On the other hand, the composite sample exhibits increased electrical resistivity due to the boron's role as electron scattering centers. Overall, this study provides a valuable strategy for the design and optimization of advanced copper-based composites with tailored mechanical and electrical properties.
Applications and emerging trends of blockchain technology in marketing to develop Industry 5.0 Businesses: A comprehensive survey and network analysis
(Elsevier B.V., 2024) Nikseresht, Ali; Shokouhyar, Sajjad; Tirkolaee, Erfan Babaee; Pishva, Nima
With the availability of enormous amounts of data come the difficulties of big data, privacy, and ransomware assaults, which result in Marketing fraud and spam. Blockchain offers an extensive array of possible applications in the Marketing field. Nevertheless, both Marketing research and practice exhibit a degree of hesitance toward using Blockchain technology and have not yet come around to completely understand and adopt the technology. Here, the aim is to examine the Blockchain concepts and their applications in Marketing through bibliometrics, network, and thematic analyses, which can provide several novel insights and perspectives into current research trends in this field by evaluating the most significant and cited research publications, keywords, institutions, authors' collaboration network, and finally countries that promote Industry 5.0 (I5.0) businesses. This study performs a detailed bibliometric and thematic-based Systematic Literature Review (SLR) on 124 of over 15000 research papers. Major outcomes include the identification of emerging themes such as the role of Blockchain in advertising, and dynamic pricing, as well as the need for further exploration of underdeveloped areas (e.g., consumer behavior and brand equity). The results contribute to theoretical and practical management elements and provide the groundwork for future study in this area. The overarching target of this research is to give a complete overview of applications and emerging trends of Blockchain technology in Marketing, thereby serving as a resource for future research topics for Marketing scholars and experts aiming to implement solutions based on Blockchain technology and algorithms to develop an I5.0 business. © 2024 Elsevier B.V.
Characterization and management of ocular events in patients treated with belantamab mafodotin plus pomalidomide and dexamethasone in the DREAMM-8 study
(CIG media group, 2024) Hang, Quach; Dimopoulos, Meletios; Beksac, Meral; Pour, Ludek; Delimpasi, Sosana; Vorobyev, Vladimir
Characterization and management of ocular events in patients treated with belantamab mafodotin plus pomalidomide and dexamethasone in the DREAMM-8 study
Changing trends in the etiology of cirrhosis in Türkiye: a multicenter nationwide study
(Aves, 2024) Üçbilek, Enver; Yıldırım, Abdullah Emre; Ellik, Zeynep; Turan, İlker; Haktanıyan, Büşra; Karatay, Eylem
Background/Aims: The aim of our study was to investigate the underlying causes behind the etiology of cirrhosis in T & uuml;rkiye.Materials and Methods: The study was comprised of patients with cirrhosis located in the gastroenterology clinics of 28 centers in T & uuml;rkiye between January 2000 and June 2021. Results: The study group consisted of 4953 cirrhotic patients (median age: 62.2 years, male / female: 58% / 42%). Among the patients, 39% of the patients were compensated, and 61% were decompensated. Furthermore, 47.5% had Child-Pugh class A, 38% had Child-Pugh class B, and 14.5% had Child-Pugh class C. The most frequent complaints were abdominal bloating (28%). Ascites (54.2%) was the most common manifestation of decompensation. The median Child-Pugh and MELD-Na scores were 7.0 and 10.0, respectively. The most common cause of cirrhosis was chronic viral hepatitis (43%), followed by cryptogenic cirrhosis (CC) (19%), metabolic dysfunc-tion-associated steatotic liver disease (MASLD)-related cirrhosis (13%), and alcohol-related cirrhosis (11%). Among the 950 patients with CC, 416 had metabolic abnormalities. If these 416 CC patients with metabolic abnormalities were categorized as having MASLD-related cirrhosis, the proportion of MASLD-related cirrhosis increased to 21%. Thirteen percent of the patients were diagnosed with HCC, while 4% had extrahepatic malignancy. Female breast cancer (18%) and colorectal cancer (18%) were the most frequent extra-hepatic malignancies. Conclusion: Viral hepatitis remains the main cause of cirrhosis in T & uuml;rkiye. However, its prevalence seems to be declining, whereas the prevalence of steatotic liver disease-related cirrhosis is increasing
