Browsing by Department "İstinye Üniversitesi, Eczacılık Fakültesi, Eczacılık Meslek Bilimleri Bölümü"
Now showing items 1-20 of 22
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Agomelatine is superior to melatonin in pain suppression: an experimental study
(AVES, 2020)Objective: Agomelatine is a synthetic analog of melatonin with selective agonist action on melatonin MT1 and MT2 receptors and antagonistic effect on serotonin 5HT2c receptors. Similar to melatonin, it also has antinociceptive ... -
Biomonitoring of heavy metal(oid)s in the residents of abandoned mining district in northern cyprus
(Springer, 2021)Abstract Several heavy metal(oid)s are known mutagens and/or carcinogens. Exposure to these elements can lead to the development of malignancies. Gemikonagi, which is in the western part of Cyprus, was the hometown of ... -
Butyrylcholinesterase-inhibiting natural coumarin molecules as potential leads
(Elsevier Ltd, 2021)Seventeen natural coumarin derivatives; badrakemin (1), 14′-acetoxybadrakemin (2), badrakemone (3), 14′-acetoxybadrakemone (4), colladonin (5), colladonin acetate (6), 14′-acetoxycolladonin (7), karatavicinol (8), deltoin ... -
Challenge-comet assay, a functional and genomic biomarker for precision risk assessment and disease prevention among exposed workers
(Academic Press Inc Elsevier Science, 2020)Advancements in genomic technologies have ushered application of innovative changes into biomedical sciences and clinical medicine. Consequently, these changes have created enormous opportunities to implement precision ... -
Cross referencing 2D-LC determination of intact gliptins in urine
(2020)Dipeptidyl peptidase-4 inhibitors, so-called gliptins, constitute a fairly novel class of oral hypoglycemic agents. The development and validation of an automated online SPE-LC-UV method to determine intact sitagliptin, ... -
Design, synthesis and cytotoxic activity of spiro(oxindole-3-3'-pyrrolidine) derivatives
(Bentham Science Publ Ltd, 2018)Background: Spiro[pyrrolidine-3,3'-oxindole] compounds are reported to be highly bioactive natural and synthetic products. Initially, spirooxindole alkaloids were isolated from plants of the Apocynaceae and Rubiaceae ... -
Determination of antibiotic resistance and pulsed-field gel electrophoresis profiles for the extended-spectrum beta-lactamase producing Escherichia coli
(Ahvaz Jundishapur Univ Med Sci, 2018)Background: Production of extended-spectrum beta-lactamase (ESBL) is one of the antibiotic resistance strategies in the bacteria. Extended spectrum beta-lactamase producing Escherichia coli (E. coli) infections alarmingly ... -
Digging deeper into precision/personalized medicine: cracking the sugar code, the third alphabet of life, and sociomateriality of the cell
(Mary Ann Liebert, Inc, 2020)Precision/personalized medicine is a hot topic in health care. Often presented with the motto "the right drug, for the right patient, at the right dose, and the right time," precision medicine is a theory for rational ... -
Drug-associated cardiovascular risks: a retrospective evaluation of withdrawn drugs
(Kare Publ, 2019)A considerable number of drugs were withdrawn from the world market in the last decades due to safety reasons. A retrospective review of withdrawals is important in determining the adequacy of regulations regarding the ... -
Evaluation of avocado (Persea americana Mill.) leaves in terms of public health
(Marmara Univ, 2018)Persea americana Mill. (Lauraceae) originated in Central and Southern of South America, is an evergreen tree. The tree is commonly known as avocado. Avocado is cultivated in all tropical and subtropical regions in the ... -
Facile microwave synthesis of a novel phenothiazine derivative and its cytotoxic activity
(ACG Publications, 2020)Herein, a facile procedure for microwave synthesis and NMR characterization of phenothiazine derivatives 10-(3-hydroxypropyl)-2-(methylsulphanyl)-10H-phenothiazine (3) (25% yield) and 1-[3-(2-methylsulfanyl-10H-phenothia ... -
Glandular trichome structures and chemical composition of the volatiles of five ribes species from Turkey
(Taylor & Francis Inc, 2019)Currant and gooseberry, the genus Ribes, is represented by eight species in the Flora of Turkey. We examined structures of glandular trichomes and composition of the essential oils from leaves of five Ribes species. The ... -
The hCOMET project: international database comparison of results with the comet assay in human biomonitoring. baseline frequency of DNA damage and effect of main confounders
(Elsevier B.V., 2021)The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those ... -
How does infection with human papillomavirus 16 and 18 impact on dna damage and repair in cervical cells and peripheral blood?
(Mary Ann Liebert, Inc, 2018)Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases worldwide and a prime cause of cervical cancer. The HPV DNA is detected in approximately 80-90% of all cervical cancers, with HPV ... -
In vitro antioxidant capacities and phenolic contents of four Erica L. (Ericaceae) taxa native to Turkey
(Marmara Univ, 2019)Erica species (Ericaceae) are widely used due to their medicinal properties in Turkish folk medicine. In this study, the antioxidant capacities of the extracts with different polarities of the aerial parts of Erica arborea, ... -
It is time to revitalize the Antibiotic Pipeline: Systems ecology can help
(Mary Ann Liebert, Inc, 2020)Antimicrobials have been known for millennia, but innovative antibiotics are currently in short supply. New antimicrobial discoveries are being threatened by planetary scale loss of biodiversity that has important impacts ... -
Preparation and evaluation of inflammation targeted nano-micellar formulation of celecoxib
(Bezmialem Vakif Univ, 2019)Objective: Celecoxib (CLX), brand named Celebrex, which belongs to non-steroidal anti-inflammatory drugs family, selectively inhibits the cytokine related cyclooxygenase-2 isoenzyme and thus, possesses less gastrointestinal ... -
Quality of turmeric powder in herbal stores: pharmacognostical investigations on turmeric powders obtained from herbal stores in Istanbul, Turkey
(ISTANBUL UNIV, 2021)Background and Aims: Curcuma longa L., known as Turmeric, has been traditionally used in Asian culture since ancient times to treat several disorders. With the increase in studies on turmeric and its major compounds, it ... -
Quinoline-based promising anticancer and antibacterial agents, and some metabolic enzyme inhibitors
(Wiley-VCH Verlag, 2020)A series of substituted quinolines was screened for their antiproliferative, cytotoxic, antibacterial activities, DNA/protein binding affinity, and anticholinergic properties by using the 3-(4,5-dimethylthiazol-2-yl)-2,5 ... -
Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathy
(Elsevier Science Bv, 2019)Introduction: Increasing number of experimental and clinical studies suggest a strong relationship between hyperglycemia, oxidative stress, DNA damage and diabetic nephropathy (DN). Also, epidemiologic studies remark an ...
