Browsing by Department "İstinye Üniversitesi, Fen-Edebiyat Fakültesi, Moleküler Biyoloji ve Genetik Bölümü Bölümü"
Now showing items 1-20 of 25
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Biallelic form of a known CD3E mutation in a patient with severe combined immunodeficiency
(Springer/Plenum Publishers, 2020)T cell receptor (TCR) complex consists of αβ or γδ TCR chains in combination with four CD3 subunits, CD3ε, CD3γ, CD3δ, and CDζ [1]. This complex is required for thymocyte development and the initiation of T cell-mediated ... -
Clinical and immunological features of 44 common variable immunodeficiency patients: The experience of a single center in Turkey
(Elsevier Doyma, 2020)Introduction and objectives: Common variable immunodeficiency (CVID) is one of the most prevalent forms of primary immunodeficiency characterized by hypogammaglobinemia. Its heterogeneous clinical features include recurrent ... -
Dual suppressive effect of miR-34a on the FOXM1/eEF2-kinase axis regulates triple-negative breast cancer growth and invasion
(Amer Assoc Cancer Research, 2018)Purpose: Recent studies indicated that dysregulation of noncoding KNAs (ncRNA) such as miRNAs is involved in pathogenesis of various human cancers. However, the molecular mechanisms underlying miR-34a are not fully understood ... -
Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target
(Springer Heidelberg, 2020)Eukaryotic elongation factor-2 kinase (eEF2K), an atypical member of alpha-kinase family, is highly overexpressed in breast, pancreatic, brain, and lung cancers, and associated with poor survival in patients. eEF2K promotes ... -
Expression analysis of lncRNA AK370814 involved in the barley vitamin B6 salvage pathway under salinity
(Springer, 2018)Long non-coding RNAs (lncRNAs), which are longer than > 200 nt, perform various functions in a variety of important biological processes. The aim of this study is the investigation of relative expression levels of AK372815 ... -
Genetic screening of the patients with primary immunodeficiency by whole-exome sequencing
(New Rochelle, 2020)Background: Primary immunodeficiencies (PIDs) are a heterogeneous group of congenital disorders characterized by susceptibility to recurrent infections, allergy, malignancies and autoimmunity. The identification of ... -
Genome organization changes in GM and non-GM soybean [Glycine max(L.) Merr.] under salinity stress by retro-transposition events
(Springer, 2020)Genetically modified (GM) crops are developed and cultivated worldwide, providing protection against insects and diseases, or tolerance to herbicides. However, despite the advantages that GM crops, they pose many concerns ... -
History and development of non-coding RNAs
(Nova Science Publishers, Inc., 2020)The recent approaches including whole-genome and RNA-sequencing (RNA-seq) studies have declared the landscape of transcription in eukaryotes is notably more complicated than had been previously appreciated. Many different ... -
Identification of microenvironmental regulation and therapeutic targeting of oncogenic eEF2K in pancreatic cancer
(Wiley, 2019)Eukaryotic elongation factor 2 kinase (eEF2K) is overexpressed in cancer cells and its overexpression is correlated with poor prognosis in several types of cancer. It has been known that pancreatic cancer (PaCa) has a ... -
IgE and IgG4 binding to lentil epitopes in children with red and green lentil allergy
(Wiley, 2020)Background The consumption of lentil is common in the Mediterranean area and is one of the causes of IgE-mediated food allergy in many countries. Len c 1 is a well-defined allergen of lentil and approximately 80% of the ... -
Invasive saprochaete capitata Infection in a patient with autosomal recessive CARD9 deficiency and a review of the literature
(Springer/Plenum Publishers, 2020)Purpose Autosomal recessive (AR) CARD9 deficiency is an inherited immune disorder which results in impaired innate immunity against various fungi. Superficial and invasive fungal infections, mainly caused by Candida or ... -
Investigation of interleukin-17 Gene-152g/A polymorphism and IL-17 Serum levels in patients with cardiac syndrome X
(Galenos Yayincilik, 2019)Objective: Cardiac syndrome X (CSX) can be defined as experiencing chest pain with angina by patients with normal coronary arteries. Endothelial and microvascular dysfunction is responsible for the pathophysiology of the ... -
Investigation of rice (Oryza sativaL.) retrotransposons in differenttaxa
(Springer, 2020)Retrotransposons are the subclass of transposable elements and they can increase their copy numbers in the genome through their copy-paste transposition mechanism. Throughout evolutionary process, their transposition events ... -
LncRNAs: genetic and epigenetic effects in plants
(Taylor & Francis Ltd, 2019)Long non-coding RNAs (lncRNAs) transcribed from the eukaryotic genome play important roles in essential biological processes, transcriptional and post-transcriptional gene regulation. LncRNAs act both in the nucleus and ... -
Long-term preservation of Cicer arietinum L. germplasm by in vitro propagation and cryopreservation
(Springer, 2020)Chickpea (Cicer arietinum L.) is one of the most important pulse worldwide. This crop plays a significant role to maintain soil fertility through symbiotic N fixation, as well as in the Mediterranean diet for its important ... -
The MTT viability assay yields strikingly false-positive viabilities although the cells are killed by some plant extracts
(Tubitak Scientific & Technical Research Council Turkey, 2017)The MTT assay is one of the often used cell viability/cytotoxicity assays. However, when the methanol extracts of plants are used to test their cytotoxic potential, interference may occur, resulting in false-positive ... -
Mutational landscape of severe combined immunodeficiency patients from Turkey
(Wiley, 2020)Severe combined immunodeficiency (SCID) has a diverse genetic aetiology, where a clinical phenotype, caused by single and/or multiple gene variants, can give rise to multiple presentations. The advent of next-generation ... -
New gene expression regulators: long non-coding RNAs
(Amer Inst Physics, 2019)Long non-coding RNAs (lncRNAs) play key roles in the regulation of biological processes including response to environmental stresses either transcriptional or post-transcriptional levels. The salinity tolerance of barley ... -
A novel 1,4-naphthoquinone-derived compound induces apoptotic cell death in breast cancer cells
(Tubitak Scientific & Technical Research Council Turkey, 2019)Breast cancer is the most-diagnosed cancer type among women. The triple-negative subtype is an especially aggressive type of breast cancer. Although chemotherapy is almost the only option for the treatment of triple-negative ...
