Browsing by Department "İstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü"
Now showing items 1-20 of 223
-
ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation
(Springer Heidelberg, 2019)2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is an abundant dietary carcinogen, formed during high-temperature cooking of meat. In this study, we investigated whether clinically relevant ATP-binding cassette (ABC) ... -
Aberrant activation-induced cytidine deaminase gene expression links BCR/ABL1-negative classical myeloproliferative neoplasms
(TR- Dizin, 2022)Aim: Activation-induced cytidine deaminase (AID) has been associated with tumor initiation and development because of its ability to generate DNA damage and somatic mutations that cause genomic instability. This study ... -
Abnormal flotation of separator gel in blood test tubes in the hemodialysis patients
(2019)Objectives: Serum-separating tubes (SST) are used in medical clinical chemistry tests requiring blood serum. Blood density is mainly dependent on the total protein concentration. Aim of this study to investigate, whether ... -
Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 + T cell subsets
(2021)Mesenchymal stem cells (MSCs) are powerful immunomodulatory cells. The effects of the aging on these abilities of MSCs have not been adequately clarified. In this study, alterations in immunomodulatory abilities of MSCs ... -
Aggressive clinicopathological course of myeloma with t(3;16) (q21;q22) cytogenetic abnormality
(Galenos Yayincilik, 2019)Multiple myeloma (MM) is a heterogeneous disease and patients present with a wide variety of cytogenetic anomalies reflecting the nature of the disease [1]. The aim of this letter is to report a rare karyotypic abnormality ... -
Analysis of serum nickel, silicium, arsenic and boron in smoking ındividuals
(DergiPark, 2021)Smoking induces inflammation and oxidative stress via radical production from chemicals resulting in cardiocerebrovascular and respiratory diseases, cancers, stroke and sudden death. Elements found in tobacco plant and ... -
Anatomi eğitimi için geliştirilmiş mobil uygulamalar
(DergiPark, 2019)Amaç: Anatomi eğitimini desteklemek için tablet ve akıllı telefonları kapsayan mobil cihazların potansiyel kullanımlarını tanımak ve mobil öğrenmeyi anatomi alanında teşvik etmektir. Gereç ve Yöntem: Araştırma ''Anatomy'', ... -
Anatomical differences of variant intracranial cysts
(NIGERIAN MEDICAL ASSOC, 2020)Cavum vergae, cavum septum pellucidum and cavum veli interpositi are brain midline embryological developmental cysts. They are rarely seen after trauma. Generally, they do not constitute clinical findings. These cysts ... -
Angiotensin IV improves spatial memory in streptozotocin‑induced diabetic rats by reducing oxidative stress and altering BDNF levels
(NCI CPTAC, 2021)In this study, we investigated the protective effects of angiotensin IV (Ang IV) on cognitive function in streptozotocin (STZ)‑induced diabetic rats. Male Wistar albino rats, were randomly divided into four groups; control ... -
Annexin A1 as a potential prognostic biomarker for COVID-19 disease: case-control study
(Wiley, 2021)Background: Annexin A1 (AnxA1) is an important endogenous glucocoticoid protein that contributes to the suppression of inflammation by limiting the production of neutrophil and proinflammatory cytokines.This study aims to ... -
Anodal transcranial direct current stimulation of the motor cortex in healthy volunteers
(Springer, 2018)Effects of anodal transcranial direct current stimulation (tDCS) of the motor cortex on heart rate variability (HRV) indices in healthy volunteers were examined. Baseline HRVs of 16 healthy subjects were recorded, and the ... -
Anti-apoptotic effects of valproic acid treatment on dopaminergic neuronal loss in a 6-hydroxydopamine model of parkinson’s disease in rats
(2022)Aim: Parkinson’s disease (PD) is characterized by the progressive loss of dopaminergic neurons resulting in deterioration of motor activity in patients. Currently, available therapies including Levodopa (L-DOPA) are more ... -
Antibodies against EGF-like domains in Ixodes scapularis BM86 orthologs impact tick feeding and survival of Borrelia burgdorferi
(Nature Publishing Group, 2021)Ixodes scapularis ticks transmit multiple pathogens, including Borrelia burgdorferi sensu stricto, and encode many proteins harboring epidermal growth factor (EGF)-like domains. We show that I. scapularis produces multiple ... -
Apelin/APJ expression in the heart and kidneys of hypertensive rats
(Elsevier Gmbh, Urban & Fischer Verlag, 2018)Hypertension is an important health problem that is manifested by systemic arterial blood pressure being permanently elevated and leading to serious complications. Hypertension is the basis for coronary heart diseases, ... -
Assessment of death risk of breast cancer patients with joint frailty models
(SAUDI MED J, 2020)Objectives: To investigate the effects of risk factors on recurrence and death in breast cancer patients, taking into account the dependence between recurrence and death as well as the heterogeneity among individuals. The ... -
Assessment of diagnostic value of ‘Human Epididymis Factor 4 (HE4)’ in women with adnexal masses
(DergiPark, 2020)Abstract Purpose: Human epididymis factor 4 (HE4) is a novel biomarker for ovarian cancer. The aim of this study is to assess the usefulness and efficacy of HE4, in comparison with CA-125 in the differential diagnosis ... -
Assessment of oxidative stress effects in serum determined by FT-IR spectroscopy in cholangiocarcinoma patients
(AMG Transcend Association, 2023)Cholangiocarcinoma (CCA) is a heterogeneous malignant tumor containing intrahepatic and extrahepatic bile ducts and gallbladder carcinoma. Mostly diagnosed at an advanced stage with a <5% cure chance. Early-stage diagnosis ... -
Assessment of structural protein expression by FTIR and biochemical assays as biomarkers of metabolites response in gastric and colon cancer
(Elsevier B.V., 2021)Colon and gastric cancers are the widespread benign types of cancers which are synchronous and metachronous neoplasms. In terms of the progression and progress of the disease, metabolic processes and differentiation in ... -
Assessment of the effect of endocrine abnormalities on biomacromolecules and lipids by FT-IR and biochemical assays as biomarker of metabolites in early Polycystic ovary syndrome women
(Elsevier, 2021)Polycystic ovary syndrome (PCOS) is a common endocrinopathy associated with metabolic disturbances.Both in the development and improvement of the disease, the structure of phospholipids and proteinsin the blood serum plays ... -
Aurasız migren hastalarının farklı frekanslardaki görsel uyarılmış potansiyeller ile değerlendirilmesi
(2020)Giriş ve Amaç: Çalışmamızın amacı, International Society for Clinical Electrophysiology of Vision (ISCEV) standartlarına göre, aurasız migren hastalarında, iki farklı kontrol boyutu (15 've 62') ile kaydedilen tersine ...
