Browsing by Department "İstinye Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü"
Now showing items 1-20 of 132
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ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation
(Springer Heidelberg, 2019)2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is an abundant dietary carcinogen, formed during high-temperature cooking of meat. In this study, we investigated whether clinically relevant ATP-binding cassette (ABC) ... -
Abnormal flotation of separator gel in blood test tubes in the hemodialysis patients
(2019)Objectives: Serum-separating tubes (SST) are used in medical clinical chemistry tests requiring blood serum. Blood density is mainly dependent on the total protein concentration. Aim of this study to investigate, whether ... -
Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 + T cell subsets
(2021)Mesenchymal stem cells (MSCs) are powerful immunomodulatory cells. The effects of the aging on these abilities of MSCs have not been adequately clarified. In this study, alterations in immunomodulatory abilities of MSCs ... -
Aggressive clinicopathological course of myeloma with t(3;16) (q21;q22) cytogenetic abnormality
(Galenos Yayincilik, 2019)Multiple myeloma (MM) is a heterogeneous disease and patients present with a wide variety of cytogenetic anomalies reflecting the nature of the disease [1]. The aim of this letter is to report a rare karyotypic abnormality ... -
Anatomi eğitimi için geliştirilmiş mobil uygulamalar
(DergiPark, 2019)Amaç: Anatomi eğitimini desteklemek için tablet ve akıllı telefonları kapsayan mobil cihazların potansiyel kullanımlarını tanımak ve mobil öğrenmeyi anatomi alanında teşvik etmektir. Gereç ve Yöntem: Araştırma ''Anatomy'', ... -
Anatomical differences of variant intracranial cysts
(NIGERIAN MEDICAL ASSOC, 2020)Cavum vergae, cavum septum pellucidum and cavum veli interpositi are brain midline embryological developmental cysts. They are rarely seen after trauma. Generally, they do not constitute clinical findings. These cysts ... -
Anodal transcranial direct current stimulation of the motor cortex in healthy volunteers
(Springer, 2018)Effects of anodal transcranial direct current stimulation (tDCS) of the motor cortex on heart rate variability (HRV) indices in healthy volunteers were examined. Baseline HRVs of 16 healthy subjects were recorded, and the ... -
Antibodies against EGF-like domains in Ixodes scapularis BM86 orthologs impact tick feeding and survival of Borrelia burgdorferi
(Nature Publishing Group, 2021)Ixodes scapularis ticks transmit multiple pathogens, including Borrelia burgdorferi sensu stricto, and encode many proteins harboring epidermal growth factor (EGF)-like domains. We show that I. scapularis produces multiple ... -
Apelin/APJ expression in the heart and kidneys of hypertensive rats
(Elsevier Gmbh, Urban & Fischer Verlag, 2018)Hypertension is an important health problem that is manifested by systemic arterial blood pressure being permanently elevated and leading to serious complications. Hypertension is the basis for coronary heart diseases, ... -
Assessment of death risk of breast cancer patients with joint frailty models
(SAUDI MED J, 2020)Objectives: To investigate the effects of risk factors on recurrence and death in breast cancer patients, taking into account the dependence between recurrence and death as well as the heterogeneity among individuals. The ... -
Assessment of structural protein expression by FTIR and biochemical assays as biomarkers of metabolites response in gastric and colon cancer
(Elsevier B.V., 2021)Colon and gastric cancers are the widespread benign types of cancers which are synchronous and metachronous neoplasms. In terms of the progression and progress of the disease, metabolic processes and differentiation in ... -
Beta globin mutations in Turkish, northern Iraqi and albanian patients with beta thalassemia major
(Pagepress Publ, 2018)The mutation detection of beta thalassemia is absolutely necessary for molecular diagnosis, as well as any genetic epidemiological study. The b globin gene has 3 exons and 2 introns, involved in beta-thalassemic pathogenesis. ... -
Bioassay-guided isolation of cytotoxic compounds from chrysophthalmum montanum (DC.) boiss
(Pergamon-Elsevier Science Ltd, 2019)Bioassay-guided isolation of the 80% methanol extract of the aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) led to the isolation of four known guaianolide-type sesquiterpene lactones, 6 alpha-acetoxy-4 ... -
Calvarial bone defects in ovariectomised rats treated with mesenchymal stem cells and demineralised freeze-dried bone allografts
(NLM (Medline), 2020)BACKGROUND: The aim of the study was to investigate the ability of a combination of bone marrow mesenchymal stem cells (BM-MSCs) with and without demineralised freeze-dried bone allografts (DFDBAs) to induce bone regeneration ... -
Can Wharton jelly derived or adipose tissue derived mesenchymal stem cell can be a treatment option for duchenne muscular dystrophy? answers as transcriptomic aspect
(2020)Introduction: Mesenchymal stem cells (MSCs) are able to differentiate into several cell lineages including skeletal muscle. In addition to their differentiation capacities, they have the ability to transfer their content ... -
Can Wharton jelly derived or adipose tissue derived mesenchymal stem cell can be a treatment option for duchenne muscular dystrophy? Answers as transcriptomic aspect
(E-CENTURY PUBLISHING CORP, 2020)Introduction: Mesenchymal stem cells (MSCs) are able to differentiate into several cell lineages including skeletal muscle. In addition to their differentiation capacities, they have the ability to transfer their content ... -
Cardiovascular changes in WAG/Rij rats with genetic absence epilepsy: effects of chronic ethosuximide treatment
(CUKUROVA UNIV, 2020)Purpose: The aim of this study was to investigate the effects of chronic ethosuximide (ETX) treatment on absence seizures and cardiovascular parameters in WAG/Rij rats with genetic absence epilepsy. Materials and Methods: ... -
A case mimicking chronic myeloid leukemia with t(8;22)(p11;q11)/BCR-FGFR1 and sequential transformation to B-acute lymphoblastic leukemia and acute myeloid leukemia
(Springer Science and Business Media Deutschland GmbH, 2021)Myeloid/lymphoid neoplasm is a rare malignancy with an aggressive course and rapid transformation to acute myeloid leukemia (AML), or less frequently to acute lymphoblastic leukemia (ALL). Cases with t(8;22)(p11;q11) ... -
Case report of a young patient with transthyretin amyloidosis associated with Gly67Ala mutation
(Taylor & Francis Ltd, 2019)Hereditary transthyretin-mediated amyloidosis (hATTR) is a rare, systemic and progressive autosomal dominant disease caused by mutations in the TTR gene. Systemic deposition of amyloidogenic mutant transthyretin results ... -
Characterization of hand clenching in human sensorimotor cortex using high-, and ultra-high frequency band modulations of electrocorticogram
(Frontiers Media Sa, 2018)Functional mapping of eloquent cortex before the resection of a tumor is a critical procedure for optimizing survival and quality of life. In order to locate the hand area of the motor cortex in two patients with low-grade ...
