by Institution Author "Taslimi, Parham"
Now showing items 1-9 of 9
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1,3-dipolar cycloaddition reactions of the compound obtaining from cyclopentadiene-PTAD and biological activities of adducts formed selectively
Yavari, Mirali Akbar; Taslimi, Parham; Bayrak, Cetin; Taskin-Tok, Tugba; Menzek, Abdullah (Wiley, 2021)After known adduct (4) was synthesized by cycloaddition reaction of cyclopentadiene with 4-phenyl-1,2,4-triazoline-3,5-dione, seven new isoxazoline derivatives were synthesized from reactions of 4 with corresponding oximes ... -
Biology-oriented drug synthesis and evaluation of secnidazole esters as novel enzyme inhibitors
Ansari, Muhammad A.; Saad, Syed M.; Khan, Khalid M.; Salar, Uzma; Taslimi, Parham; Taskin-Tok, Tugba; Saleem, Faiza; Jahangir, Sajid (Wiley, 2021)The identification of novel compounds that can inhibit physiologically and metabolically important drug targets or enzymes has prime importance in medicinal chemistry. With this aim, a range of secnidazole esters 1–30 were ... -
Cytotoxic effect, spectroscopy, DFT, enzyme inhibition, and moleculer docking studies of some novel mesitylaminopropanols: antidiabetic and anticholinergics and anticancer potentials
Khalilov, Ali N.; Tüzün, Burak; Taslimi, Parham; Tas, Ayca; Tuncbilek, Zuhal; Cakmak, Nese Keklikcioglu (Elsevier, 2021)β-Amino alcohols (2–4) used in this study were re-synthesized in accordance with our previous study. All compounds were characterized by the combination of NMR, UV–Vis, IR experimental and theoretical spectral data. Then, ... -
Cytotoxicity effects and biochemical investigation of novel tetrakis-phthalocyanines bearing 2-thiocytosine moieties with molecular docking studies
Gunsel, A.; Yildirim, A.; Taslimi, P.; Erden, Y.; Taskin-Tok, T. (Elsevier, 2022)In this study, the novel 3-(4-aminopyrimidin-2-ylthio) phthalonitrile (1) as starting material was synthesized and its molecular structure was verified by the experiment of single crystal X-ray diffraction, and it was first ... -
Fatty acid composition, enzyme inhibitory effect, antioxidant and anticancer activity of extract from Saponaria prostrata WILLD. subsp. anatolica HEDGE
Erdogan, Mehmet Kadir; Gecibesler, Ibrahim Halil; Yapar, Yakup; Gundogdu, Ramazan; Kirici, Mahinur; Behcet, Lutfi; Taslimi, Parham (Elsevier, 2021)This study attempts to evaluate the antioxidant, enzyme inhibitory, and anticancer properties as well as fatty acid compositions of endemic Saponaria prostrata WILLD. subsp. anatolica HEDGE. The gas chromatography-mass ... -
Novel tetrakis-phthalocyanines bearing pyrimidine derivative: crystal XRD analysis, enzyme inhibition, molecular docking, and anticancer effects
Gunsel, Armagan; Yazar, Bilge; Taslimi, Parham; Erden, Yavuz; Taskin-Tok, Tugba; Piskin, Hasan (Taylor & Francis Online, 2021)In this study, the novel 4-(4-Aminopyrimidin-2-ylthio) phthalonitrile (1) as starting material was synthesized and its 3D structure was verified by the single crystal X-ray diffraction experiment. Then, its peripherally ... -
Potential thiosemicarbazone-based enzyme inhibitors: assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations
Yakan, Hasan; Kocyigit, Umit M; Muglu, Halit; Ergul, Mustafa; Erkan, Sultan; Guzel, Emre; Taslimi, Parham; Gulcin, Ilhami (2022)A new series of thiosemicarbazone derivatives (1-11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform ... -
Silver N-heterocyclic carbene complexes bearing fluorinated benzyl group: synthesis, characterization, crystal structure, computational studies, and inhibitory properties against some metabolic enzymes
Bal, Selma; Demirci, Ozlem; Sen, Betul; Taskin Tok, Tugba; Taslimi, Parham; Aktas, Aydin; Gok, Yetkin; Aygun, Muhittin; Gulcin, Ilhami (WILEY, 2021)A series of the silver N-heterocyclic carbene (NHC) complexes have been synthesized from the reactions between benzimidazolium salts bearing fluorinated benzyl group and Ag2O via the deprotonation method. All Ag(I)NHC ... -
Synthesis, biological activity and docking calculations of bis-naphthoquinone derivatives from Lawsone
Riaz, Muhammad Tariq; Yaqub, Muhammad; Shafiq, Zahid; Ashraf, Abida; Khalid, Muhammad Umar; Taslimi, Parham; Taş, Recep; TÜzÜn, Burak; Gülçın, Ìlhami (Academic Press Inc., 2021)Some metabolic enzyme inhibitors can be used as Multi-target-Directed-Ligands (MTDL) in Medicinal chemistry therefore, synthesis and determination of alternative inhibitors are essential. In this study, novel bis-napthoquinone ...
