Browsing by Subject "Abc Transporters"

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ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation

Durmus, Selvi; van der Valk, M.; Teunissen, S. F.; Song, J. Y.; Wagenaar, E.; Beijnen, J. H.; Schinkel, A. H. (Springer Heidelberg, 2019)

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is an abundant dietary carcinogen, formed during high-temperature cooking of meat. In this study, we investigated whether clinically relevant ATP-binding cassette (ABC) ...