Browsing by Author "Özkan, Tülin"

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Characterization of imatinib-resistant K562 cell line displaying resistance mechanisms

Hekmatshoar, Yalda; Özkan, Tülin; Güneş, Buket Altınok; Bozkurt, Süreyya; Karadağ, Aynur; Karabay, Arzu Zeynep; Sunguroğlu, Asuman (C M B Assoc, 2018)

Chronic myeloid leukemia (CML) is a hematopoietic malignancy characterized by the t(9; 22) and the related oncogene, BCR-ABL. Tyrosine kinase activity of fusion protein BCR-ABL is the main cause of CML. Even if imatinib ...
Downregulation of stearoyl-CoA desaturase 1 (SCD-1) promotes resistance to imatinib in chronic myeloid leukemia

Günes, Buket Altınok; Hekmatshoar, Yalda; Özkan, Tülin; Bozkurt, Süreyya; Aydos, Oya Sena Erdoğan; Büyükaşık, Yahya; Aladağ, Elifcan; Asuman Sunguroğlu (Mattioli 1885, 2022)

Chronic myeloid leukemia (CML) is a malignant hematopoietic stem cell disease resulting in the fusion of BCR and ABL genes and characterized by the presence of the reciprocal translocation t(9;22)(q34;q11). BCR-ABL, a ...