Browsing by Author "Alper, Pinar"
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Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity
Genckal, Hasene; Erkisa Genel, Merve; Alper, Pinar; Sahin, Saliha; Ulukaya, Engin; Ari, Ferda (Springer, 2020)In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2 '-bipyiridine) ligands. The obtained Ni(II) and Co(II) complexes are new and the ... -
Palladium(II) and platinum(II) saccharinate complexes with bis(diphenylphosphino)methane/ethane: synthesis, S-phase arrest and ROS-mediated apoptosis in human colon cancer cells
Icsel, Ceyda; Yilmaz, Veysel T.; Aygun, Muhittin; Cevatemre, Buse; Alper, Pinar; Ulukaya, Engin (Royal Soc Chemistry, 2018)New neutral [M(sac)(2)(diphos)] and cationic [M(diphos)(2)](sac)(2) complexes, where M = Pd-II or Pt-II, sac = saccharinate, and diphos = 1,1-bis(diphenylphosphino)methane (dppm) or 1,2-bis(diphenylphosphino)ethane (dppe), ... -
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
Cevatemre, Buse; Erkisa Genel, Merve; Aztopal, Nazlihan; Karakas Zeybek, Didem; Alper, Pinar; Tsimplouli, Chrisiida; Sereti, Evangelia; Dimas, Konstantinos; Armutak, Elif I. Ikitimur; Gurevin, Ebru Gurel; Uvez, Ayca; Mori, Mattia; Berardozzi, Simone; Ingallina, Cinzia; D'Acquarica, Ilaria; Botta, Bruno; Ozpolat, Bulent; Ulukaya, Engin (Academic Press Ltd- Elsevier Science Ltd, 2018)Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the ... -
Soloxolone methyl, as a 18βH-glycyrrhetinic acid derivate, may result in endoplasmic reticulum stress to induce apoptosis in breast cancer cells
Alper, Pinar; Salomatina, Oksana V.; Salakhutdinov, Nariman F.; Ulukaya, Engin; Ari, Ferda (Elsevier Ltd, 2021)Being one of the leading causes of cancer death among women, various chemotherapeutic agents isolated from natural compounds are used in breast cancer treatment and consequently studies to develop new drugs still continue. ... -
Synthesis, characterization, anticancer and antioxidant activity of new nickel(II) and copper(II) flavonoid complexes
Alper, Pinar; Erkisa Genel, Merve; Genckal, Hasene Mutlu; Sahin, Saliha; Ulukaya, Engin; Ari, Ferda (Elsevier, 2019)Flavonoids are natural products which are known to have biological activity for human health. In this study, new mixed ligand complexes of Ni(II) and Cu(II) were synthesized by using flavonoid (quercetin or naringenin) and ...
