Browsing by Author "Ari, Ferda"
Now showing items 1-20 of 20
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Combination of histone deacetylase inhibitor with Cu(II) 5,5- diethylbarbiturate complex induces apoptosis in breast cancer stem cells: a promising novel approach
Background: Cancer stem cells (CSC) are subpopulation within the tumor that acts a part in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes ... -
Cytotoxic and genotoxic effects of an endemic plant of Turkey salvia kronenburgii on breast cancer cell lines
Cebi, Aysegul; Akgun, Egemen; Celikler, Serap; Firat, Mehmet; Ozel, Mustafa Zafer; Ulukaya, Engin; Ari, Ferda (Wolters Kluwer Medknow Publications, 2019)Context: The natural products derived from plants are the important sources that can be used for breast cancer treatment. Salvia species and their derived products were recommended as potential antitumor substances. Aim: ... -
Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect
Buz, Pelin Turhan; Duman, Fatma Demir; Erkisa Genel, Merve; Demirci, Gozde; Ari, Ferda; Ulukaya, Engin; Acar, Havva Yagci (Future Medicine Ltd, 2019)Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their ... -
Effective and new potent drug combination: histone deacetylase and Wnt/beta-catenin pathway inhibitors in lung carcinoma cells
Akgun, Oguzhan; Erkisa Genel, Merve; Ari, Ferda (Wiley, 2019)Lung cancer is the most commonly diagnosed cancer worldwide with a high mortality rate. In this study, the therapeutic effect of combination valproic acid and niclosamide was investigated on human lung cancer cell line. ... -
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line
Aydinlik, Seyma; Erkisa, Merve; Cevatemre, Buse; Sarimahmut, Mehmet; Dere, Egemen; Ari, Ferda; Ulukaya, Engin (Elsevier Science Bv, 2017)Background: The outcome of triple negative breast cancer is still poor and requires improvement with better therapy options. Autophagy has recently been shown to play a role in anticancer drug resistance. Therefore, we ... -
Epigenetic modulators combination with chemotherapy in breast cancer cells
Ari, Ferda; Napieralski, Rudolf; Akgun, Oguzhan; Magdolen, Viktor; Ulukaya, Engin (Wiley, 2021)Despite the concerning adverse effects on tumour development, epigenetic drugsare very promising in cancer treatment. The aim of this study was to compare the dif-ferential effects of standard chemotherapy regimens (FEC: ... -
Etoposide loaded SPION-PNIPAM nanoparticles improve the in vitro therapeutic outcome on metastatic prostate cancer cells via enhanced apoptosis
Erkisa Genel, Merve; Ari, Ferda; Ulku, Irem; Khodadust, Rouhollah; Yar, Yasemin; Acar, Havva Yagci; Ulukaya, Engin (2020)Prostate cancer is among the leading causes of death worldwide because its metastatic form is a deadly disease. Therefore, the development of new chemotherapeutics is of immense importance. Nanoparticle technology seems ... -
Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells
Duman, Fatma Demir; Erkisa, Merve; Khodadust, Rouhullah; Ari, Ferda; Ulukaya, Engin; Acar, Havva Yagci (Future Medicine Ltd, 2017)We aim to develop folic acid ( FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug ... -
Lichens exerts an anti-proliferative effect on human breast and lung cancer cells through induction of apoptosis
Ozturk, Sule; Erkisa Genel, Merve; Oran, Oran; Ulukaya, Engin; Celikler, Serap; Ari, Ferda (Taylor and Francis Ltd, 2019)Successful cancer treatment still requires new complexes or compounds from natural sources. Therefore, we investigated anti-growth/apoptotic effects of methanol extracts of the lichen species (Xanthoparmelia somloensis ... -
Mixed ligand complexes of Co(II), Ni(II) and Cu(II) with quercetin and diimine ligands: synthesis, characterization, anti-cancer and anti-oxidant activity
Genckal, Hasene; Erkisa Genel, Merve; Alper, Pinar; Sahin, Saliha; Ulukaya, Engin; Ari, Ferda (Springer, 2020)In this work, mixed ligand complexes of Co(II) Ni(II) and Cu(II) were synthesized using quercetin and diimine (1,10-phenanthroline or 2,2 '-bipyiridine) ligands. The obtained Ni(II) and Co(II) complexes are new and the ... -
The MTT viability assay yields strikingly false-positive viabilities although the cells are killed by some plant extracts
Karakas Zeybek, Didem; Ari, Ferda; Ulukaya, Engin (Tubitak Scientific & Technical Research Council Turkey, 2017)The MTT assay is one of the often used cell viability/cytotoxicity assays. However, when the methanol extracts of plants are used to test their cytotoxic potential, interference may occur, resulting in false-positive ... -
Nonapoptotic cell death induced by Hypericum species on cancer cells
Objectives. There are approximately 400 Hypericum species that grow naturally in different geographic originsof the world. Those species have been used in different folk medicines and screened for their biological ... -
Novel 1-(7-ethoxy-1-benzofuran-2-yl) substituted chalcone derivatives: synthesis, characterization and anticancer activity
Coskun, Demet; Erkisa, Merve; Ulukaya, Engin; Coskun, Mehmet Fatih; Ari, Ferda (Elsevier France-Editions Scientifiques Medicales Elsevier, 2017)Cancer treatment still requires new compounds to be discovered. Chalcone and its derivatives exhibit anticancer potential in different cancer cells. A new series of benzofuran substituted chalcone derivatives was synthesized ... -
Palladium (II) complex enhances ROS-dependent apoptotic effects via autophagy inhibition and disruption of multiple signaling pathways in colorectal cancer cells
Background: Inhibition of autophagy is reported to be a therapeutically effective strategy in overcoming the resistance that is a deadly outcome in cancer. One of the most common reasons for chemo-resistance to treatment ... -
Quantification of DNA damage products by gas chromatography tandem mass spectrometry in lung cell lines and prevention effect of thyme antioxidants on oxidative induced DNA damage
Aybastier, Onder; Dawbaa, Sam; Demir, Cevdet; Akgun, Oguzhan; Ulukaya, Engin; Ari, Ferda (Elsevier Science Bv, 2018)Lung cancer has a high treatment cost and poor prognosis in comparison to other types of cancers. This work was involved in studying oxidative DNA base damage inhibition. Accordingly, standard carvacrol, thymol, thymoquinone ... -
Soloxolone methyl, as a 18βH-glycyrrhetinic acid derivate, may result in endoplasmic reticulum stress to induce apoptosis in breast cancer cells
Alper, Pinar; Salomatina, Oksana V.; Salakhutdinov, Nariman F.; Ulukaya, Engin; Ari, Ferda (Elsevier Ltd, 2021)Being one of the leading causes of cancer death among women, various chemotherapeutic agents isolated from natural compounds are used in breast cancer treatment and consequently studies to develop new drugs still continue. ... -
Synthesis, characterization, anticancer and antioxidant activity of new nickel(II) and copper(II) flavonoid complexes
Alper, Pinar; Erkisa Genel, Merve; Genckal, Hasene Mutlu; Sahin, Saliha; Ulukaya, Engin; Ari, Ferda (Elsevier, 2019)Flavonoids are natural products which are known to have biological activity for human health. In this study, new mixed ligand complexes of Ni(II) and Cu(II) were synthesized by using flavonoid (quercetin or naringenin) and ... -
Toxicity assessment of Hypericum olympicum subsp. olympicum L. on human lymphocytes and breast cancer cell lines
Balikci, Necmiye; Sarimahmut, Mehmet; Ari, Ferda; Aztopal, Nazlihan; Ozel, Mustafa Zafer; Ulukaya, Engin; Celikler, Serap (Univ South Bohemia, 2020)There is a limited number of studies about the constituents of Hypericum olympicum subsp. olympicum and its genotoxic and cytotoxic potency. We examined the possible antigenotoxic/genotoxic properties of methanolic extract ... -
A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer
Aztopal, Nazlihan; Karakas, Didem; Cevatemre, Buse; Ari, Ferda; Icsel, Ceyda; Daidone, Maria G.; Ulukaya, Engin (Pergamon-Elsevier Science Ltd, 2017)Recent accumulating evidence has supported the notion that tumors have hierarchically organized heterogeneous cell populations and a small subpopulation of cells, termed cancer stem cells (CSCs), are responsible for tumor ... -
Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells
Aztopal, Nazlihan; Erkisa Genel, Merve; Ertürk, Elif; Ulukaya, Engin; Tokullugil, Asuman Hatice; Ari, Ferda (Elsevier Ireland Ltd, 2018)Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, ...
