Browsing by Author "Aydinlik, Seyma"
Now showing items 1-6 of 6
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Bioassay-guided isolation of cytotoxic compounds from chrysophthalmum montanum (DC.) boiss
Ayaz, Fatma; Kucukboyaci, Nurgun; Goren, Nezhun; Calis, Ihsan; Aydinlik, Seyma; Ulukaya, Engin; Duman, Hayri; Choudhary, Muhammad Iqbal (Pergamon-Elsevier Science Ltd, 2019)Bioassay-guided isolation of the 80% methanol extract of the aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) led to the isolation of four known guaianolide-type sesquiterpene lactones, 6 alpha-acetoxy-4 ... -
Chloroquine used in combination with chemotherapy synergistically suppresses growth and angiogenesis in vitro and in vivo
Gurel-Gurevin, Ebru; Kiyan, Hulya Tuba; Esener, Osman Behzat Burak; Aydinlik, Seyma; Uvez, Ayca; Ulukaya, Engin; Dimas, Konstantinos; Armutak, Elif Ilkay (Int Inst Anticancer Research, 2018)Background: The inhibition of autophagy using pharmacological inhibitors such as chloroquine may be an effective strategy to overcome chemotherapy or resistance to anti-angiogenic therapy. Materials and Methods: The cytotoxic ... -
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line
Aydinlik, Seyma; Erkisa, Merve; Cevatemre, Buse; Sarimahmut, Mehmet; Dere, Egemen; Ari, Ferda; Ulukaya, Engin (Elsevier Science Bv, 2017)Background: The outcome of triple negative breast cancer is still poor and requires improvement with better therapy options. Autophagy has recently been shown to play a role in anticancer drug resistance. Therefore, we ... -
Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells
Aydinlik, Seyma; Dere, Egemen; Ulukaya, Engin (Elsevier, 2019)Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces ... -
Palladium (II) complex and thalidomide intercept angiogenic signaling via targeting FAK/Src and Erk/Akt/PLC gamma dependent autophagy pathways in human umbilical vein endothelial cells
Aydinlik, Seyma; Uvez, Ayca; Kiyan, Hulya Tuba; Gurel-Gurevin, Ebru; Yilmaz, Veysel Turan; Ulukaya, Engin (Elsevier, 2021)The current study assessed the effects of the thalidomide and palladium (II) saccharinate complex of terpyridine on the suppression of angiogenesis-mediated cell proliferation. The viability was assessed after treatment ... -
Palladium (II) complex enhances ROS-dependent apoptotic effects via autophagy inhibition and disruption of multiple signaling pathways in colorectal cancer cells
Background: Inhibition of autophagy is reported to be a therapeutically effective strategy in overcoming the resistance that is a deadly outcome in cancer. One of the most common reasons for chemo-resistance to treatment ...
