Browsing by Author "Aztopal, Nazlıhan"
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Key actors in cancer therapy: epigenetic modifiers
Akar, Remzi Okan; Selvi, Selin; Ulukaya, Engin; Aztopal, Nazlıhan (Tubitak Scientific & Technical Research Council Turkey, 2019)Epigenetic reprogramming plays a crucial role in the tumorigenicity and maintenance of tumor-specific gene expression that especially occurs through DNA methylation and/or histone modifications. It has well-defined mechanisms. ... -
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
Cevatemre, Buse; Erkısa Genel, Merve; Aztopal, Nazlıhan; Karakaş Zeybek, Didem; Alper, Pınar; Tsimplouli, Chrisiida; Sereti, Evangelia; Dimas, Konstantinos; Armutak, Elif I. İkitimur; Gürevin, Ebru Gürel; Üvez, Ayça; Mori, Mattia; Berardozzi, Simone; Ingallina, Cinzia; D'Acquarica, Ilaria; Botta, Bruno; Özpolat, Bülent; Ulukaya, Engin (Academic Press Ltd- Elsevier Science Ltd, 2018)Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the ... -
A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex
Erkısa Genel, Merve; Aydınlık, Şeyma; Cevatemre, Buse; Aztopal, Nazlıhan; Akar, Remzi Okan; Çelikler, Serap; Yılmaz, Veysel Turan; Ari, Ferda; Ulukaya, Engin (Elsevier B.V., 2020)Autophagy is a catabolic process for cells that can provide energy sources and allows cancer cells to evade cell death. Therefore, studies on the combination of autophagy inhibitors with drugs are increasing as a new ...
