Browsing by Author "Aztopal, Nazlihan"
Now showing items 1-9 of 9
-
Combination of histone deacetylase inhibitor with Cu(II) 5,5- diethylbarbiturate complex induces apoptosis in breast cancer stem cells: a promising novel approach
Background: Cancer stem cells (CSC) are subpopulation within the tumor that acts a part in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes ... -
Key actors in cancer therapy: epigenetic modifiers
Akar, Remzi Okan; Selvi, Selin; Ulukaya, Engin; Aztopal, Nazlihan (Tubitak Scientific & Technical Research Council Turkey, 2019)Epigenetic reprogramming plays a crucial role in the tumorigenicity and maintenance of tumor-specific gene expression that especially occurs through DNA methylation and/or histone modifications. It has well-defined mechanisms. ... -
Nonapoptotic cell death induced by Hypericum species on cancer cells
Objectives. There are approximately 400 Hypericum species that grow naturally in different geographic originsof the world. Those species have been used in different folk medicines and screened for their biological ... -
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
Cevatemre, Buse; Erkisa Genel, Merve; Aztopal, Nazlihan; Karakas Zeybek, Didem; Alper, Pinar; Tsimplouli, Chrisiida; Sereti, Evangelia; Dimas, Konstantinos; Armutak, Elif I. Ikitimur; Gurevin, Ebru Gurel; Uvez, Ayca; Mori, Mattia; Berardozzi, Simone; Ingallina, Cinzia; D'Acquarica, Ilaria; Botta, Bruno; Ozpolat, Bulent; Ulukaya, Engin (Academic Press Ltd- Elsevier Science Ltd, 2018)Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the ... -
A promising therapeutic combination for metastatic prostate cancer: Chloroquine as autophagy inhibitor and palladium(II) barbiturate complex
Erkisa Genel, Merve; Aydinlik S.; Cevatemre B.; Aztopal, Nazlihan; Akar, Remzi Okan; Celikler S.; Yilmaz, V.T; Ari, F.; Ulukaya, Engin (Elsevier B.V., 2020)Autophagy is a catabolic process for cells that can provide energy sources and allows cancer cells to evade cell death. Therefore, studies on the combination of autophagy inhibitors with drugs are increasing as a new ... -
Toxicity assessment of Hypericum olympicum subsp. olympicum L. on human lymphocytes and breast cancer cell lines
Balikci, Necmiye; Sarimahmut, Mehmet; Ari, Ferda; Aztopal, Nazlihan; Ozel, Mustafa Zafer; Ulukaya, Engin; Celikler, Serap (Univ South Bohemia, 2020)There is a limited number of studies about the constituents of Hypericum olympicum subsp. olympicum and its genotoxic and cytotoxic potency. We examined the possible antigenotoxic/genotoxic properties of methanolic extract ... -
A trans-platinum(II) complex induces apoptosis in cancer stem cells of breast cancer
Aztopal, Nazlihan; Karakas, Didem; Cevatemre, Buse; Ari, Ferda; Icsel, Ceyda; Daidone, Maria G.; Ulukaya, Engin (Pergamon-Elsevier Science Ltd, 2017)Recent accumulating evidence has supported the notion that tumors have hierarchically organized heterogeneous cell populations and a small subpopulation of cells, termed cancer stem cells (CSCs), are responsible for tumor ... -
Valproic acid, a histone deacetylase inhibitor, induces apoptosis in breast cancer stem cells
Aztopal, Nazlihan; Erkisa Genel, Merve; Ertürk, Elif; Ulukaya, Engin; Tokullugil, Asuman Hatice; Ari, Ferda (Elsevier Ireland Ltd, 2018)Cancer stem-like cells (CSCs) are a cell subpopulation that can reinitiate tumors, resist chemotherapy, give rise to metastases and lead to disease relapse because of an acquired resistance to apoptosis. Especially, ...
