Browsing by Author "Bal Öztürk, Ayça"
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Advancements and future directions in the antibacterial wound dressings - a review
Bal Öztürk, Ayça; Özkahraman, Bengi; Özbaş, Zehra; Yaşayan, Gökçen; Tamahkar, Emel; Alarçin, Emine (2021)Wound repair is a complex process that has not been entirely understood. It can conclude in several irregularities. Hence, designing an appropriate wound dressing that can accelerate the healing period is critical. Infections, ... -
Aloe vera-based antibacterial porous sponges for wound dressing applications
Tamahkar, Emel; Özkahraman, Bengi; Özbaş, Zehra; İzbudak, Burçin; Yarımcan, Filiz; Boran, Filiz; Bal Öztürk, Ayça (SPRINGER, 2021)The antibacterial sponges with high macroporosity, high interconnectivity and high biocompatibility is a significant concern for wound healing applications. In this work, novel Aloe vera (AV) based sponges were developed ... -
Boric acid-impregnated silk fibroin/gelatin/hyaluronic acid-based films for improving the wound healing process
Özen, Nurten; Özbaş, Zehra; İzbudak, Burçin; Emik, Serkan; Özkahraman, Bengi; Bal Öztürk, Ayça (Journal of Applied Polymer Science, 2021)Recently, with the progression in wound dressings, the importance of the biocompatible material with enhanced features for potential applications in the biomedical field has been more developed. Current strategies focus ... -
Chitosan/collagen composite films as wound dressings encapsulating allantoin and lidocaine hydrochloride
Yaşayan, Gökçen; Karaca, Gizem; Püren Akgüner, Zeynep; Bal Öztürk, Ayça (Taylor & Francis As, 2020)Chitosan/collagen composite scaffolds encapsulating allantoin and lidocaine hydrochloride were formulated in various ratios and characterized in vitro for their applications in wound healing. After fabrication, scaffolds ... -
Combination therapy using nanomaterials and stem cells to treat spinal cord injuries
Zarepour, Arezou; Bal Öztürk, Ayça; Koyuncu Irmak, Duygu; Yaşayan, Gökçen; Gökmen, Aylin; Karaöz, Erdal; Zarepour, Atefeh; Zarrabi, Ali; Mostafavi, Ebrahim (Elsevier Science, 2022)As a part of the central nervous system, the spinal cord (SC) provides most of the communications between the brain and other parts of the body. Any damage to SC interrupts this communication, leading to serious ... -
Controlled release profile of 5-fluorouracil loaded P(AAM-co-NVP-co-DEAEMA) microgel prepared via free radical precipitation polymerization
Özbaş, Zehra; Özkahraman, Bengi; Bal Öztürk, Ayça (Springer, 2018)A new microgel was prepared by free radical precipitation polymerization of acrylamide (AAM), 1-vinyl-2-pyrrolidone (NVP) and 2-(diethylamino)ethyl methacrylate (DEAEMA) to be used for the controlled drug release. The ... -
Current strategies and future perspectives of skin-on-a-chip platforms: innovations, technical challenges and commercial outlook
Bal Öztürk, Ayça; Miccoli, Beatrice; Avcı Adalı, Meltem; Mogtader, Ferzaneh; Sharifi, Fatemeh; Cecen, Berivan; Yaşayan, Gökçen; Braeken, Dries; Alarçin, Emine (Bentham Science Publ Ltd, 2018)The skin is the largest and most exposed organ in the human body. Not only it is involved in numerous biological processes essential for life but also it represents a significant endpoint for the application of pharmaceuticals. ... -
Current strategies for the regeneration of skeletal muscle tissue
Alarçın, Emıne; Bal Öztürk, Ayça; Avcı, Hüseyin; Ghorbanpoor, Hamed; Güzel, Fatma Doğan; Akpek, Ali; Yeşiltaş, Gözde; Canak İpek, Tuba; Avcı Adalı, Meltem (MDPI AG, 2021)Traumatic injuries, tumor resections, and degenerative diseases can damage skeletal muscle and lead to functional impairment and severe disability. Skeletal muscle regeneration is a complex process that depends on various ... -
Design of an amphiphilic hyperbranched core/shell-type polymeric nanocarrier platform for drug delivery
Bal Öztürk, Ayça; Oğuz, Nesrin; Tekarslan Şahin, Hande; Emik, Serkan; Alarcin, Emine (TUBITAK, 2022)An amphiphilic core/shell-type polymer-based drug carrier system (HPAE- PCL-b-MPEG), composed of hyperbranched poly(aminoester)-based polymer (HPAE) as the core building block and poly(ethylene glycol)-bpoly(ε-caprolactone) ... -
Development and characterization of oxaceprol-loaded poly-lactide-co-glycolide nanoparticles for the treatment of osteoarthritis
Alarçin, Emine; Demirbağ, Çağlar; Karslı Ceppioğlu, Seher; Kerinnoğlu, Oya; Bal Öztürk, Ayça (Wiley, 2020)Oxaceprol is well-defined therapeutic agent as an atypical inhibitor of inflammation in osteoarthritis. In the present study, we aimed to develop and characterize oxaceprol-loaded poly-lactide-co-glycolide (PLGA) nanoparticles ... -
Development of mucoadhesive modified kappa-carrageenan/pectin patches for controlled delivery of drug in the buccal cavity
Özkahraman, Bengi; Özbaş, Zehra; Yaşayan, Gökçen; Püren Akgüner, Zeynep; Yarımcan, Filiz; Alarçin, Emine; Bal Öztürk, Ayça (Wiley, 2021)In this study, modified kappa-carrageenan/pectin hydrogel patches were fabricated for treatment of buccal fungal infections. For this purpose, kappa-carrageenan-g-acrylic acid was modified with different thiolated agents ... -
The effect of LDHs nanoparticles on the cellular behavior of stem cell-laden 3D-bioprinted scaffold
İzbudak, Burçin; Bal Öztürk, Ayça (SAGE PUBLICATIONS, 2022)Three-dimensional (3D)-bioprinting as an emerging approach for tissue engineering possesses the promise to create highly mimicked organs or tissues by using computer-aided design. For biomedical applications in tissue ... -
The effect of thiol functional groups on bovine serum albumin/chitosan buccal mucoadhesive patches
Bal Öztürk, Ayça; Alarçin, Emine; Özbaş, Zehra; Özkahraman, Bengi; Torkay, Gülşah (Editions de Sante, 2022)In this research, the effect of thiol functional groups on bovine serum albumin (BSA)/chitosan (Chi) based buccal mucoadhesive patch was investigated. Thiolated BSA (BSA-SH) was prepared via 2-mercaptoethanol. FTIR and 1H ... -
The effect of vitamin c in the formulation of pectin/thiolated alginate buccal adhesive patches: in vitro and ex vivo evaluation
Özkahraman, Bengi; Torkay, Gülşah; Özbaş, Zehra; Bal Öztürk, Ayça (Elsevier Ltd., 2022)The present study outlines the prospect of a pectin (Pec)/modified alginate (Alg) buccal patch as drug delivery device in the localized treatment of oral cavity diseases. Firstly, Alg was modified with acrylic acid, and ... -
Enzyme-mediated Alleviation of Peroxide Toxicity in Self-oxygenating Biomaterials
Willemen, Niels G. A.; Hassan, Shabir; Gurian, Melvin; Jasso-Salazar, Maria Fernanda; Fan, Kai; Wang, Haihang; Becker, Malin; Allijn, Iris E.; Bal Öztürk, Ayça; Leijten, Jeroen; Shin, Su Ryon (2022)Oxygen releasing biomaterials can facilitate the survival of living implants by creating environments with a viable oxygen level. Hydrophobic oxygen generating microparticles (HOGMPs) encapsulated calcium peroxide (CPO) ... -
Evaluation of modified pectin/alginate buccal patches with enhanced mucoadhesive properties for drug release systems: in-vitro and ex-vivo study
Özbaş, Zehra; Özkahraman, Bengi; Püren Akgüner, Zeynep; Bal Öztürk, Ayça (Editions de Sante, 2022)A recent approach for buccal mucoadhesive system is the production of thiolated polymers via thiomer. In this study, pectin was grafted with acrylic acid before the thiolation by L-cystein and it was characterized by FTIR, ... -
Evolution and clinical translation of drug delivery nanomaterials
Hassan, Shabir; Prakash, Gyan; Bal Öztürk, Ayça; Saghazadeh, Saghi; Sohail, Muhammad Farhan; Seo, Jungmok; Khademhosseini, Ali (Elsevier Sci Ltd, 2017)With the advent of technology, the role of nanomaterials in medicine has grown exponentially in the last few decades. The main advantage of such materials has been exploited in drug delivery applications, due to their ... -
Functionalized 2-(hydroxyethyl) methacrylate (HEMA)-co-acrylamide (AAm) hydrogels: kinetic and isotherm modelling analysis on the removal of Cu(II) Ions
Bal Öztürk, Ayça; Özbaş, Zehra; Özkahraman, Bengi; Emik, Serkan (Prints Publications Pvt Ltd, 2019)A functionalized hydrogel composed of 2-(hydroxyethyl) methacrylate (HEMA) and acrylamide (AAm) was synthesized by amination and saponification reactions, respectively, and its functionality was examined for the elimination ... -
Gelatin methacryloyl/nanosilicate nanocomposite hydrogels encapsulating dexamethasone with a tunable crosslinking density for bone repair
Alarçin, Emine; Dokgöz, Ayşe Begüm; Akgüner Püren, Zeynep; Seki, Hatice Kübra; Bal Öztürk, Ayça (Editions de Sante, 2022)Despite various strategies have been proposed to accelerate bone regeneration, the treatment of bone defects in critical size still remains a clinical challenge. In this study, we fabricated nanocomposite gelatin methacryloyl ... -
In-vitro bioactivity investigation of sol-gel derived alumina-bovine hydroxyapatite (Bha) composite powders
Yelten, Azade; Karal Yılmaz, Okşan; Püren Akgüner, Zeynep; Bal Öztürk, Ayça; Yılmaz, Suat (Gazi Universitesi, 2020)Alumina (α-Al2O3) and hydroxyapatite (HA, Ca10(PO4)6(OH)2) are well-known for being clinically successful bioceramic materials. In this work, in-vitro biological characterization of the sol-gel alumina-bovine hydroxyapatite ...
