Browsing by Author "Bozkurt, Süreyya"
Now showing items 1-12 of 12
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Aggressive clinicopathological course of myeloma with t(3;16) (q21;q22) cytogenetic abnormality
Bozkurt, Süreyya; Okay, Mufide; Haznedaroğlu, İbrahim (Galenos Yayincilik, 2019)Multiple myeloma (MM) is a heterogeneous disease and patients present with a wide variety of cytogenetic anomalies reflecting the nature of the disease [1]. The aim of this letter is to report a rare karyotypic abnormality ... -
Characterization of imatinib-resistant K562 cell line displaying resistance mechanisms
Hekmatshoar, Yalda; Özkan, Tülin; Güneş, Buket Altınok; Bozkurt, Süreyya; Karadağ, Aynur; Karabay, Arzu Zeynep; Sunguroğlu, Asuman (C M B Assoc, 2018)Chronic myeloid leukemia (CML) is a hematopoietic malignancy characterized by the t(9; 22) and the related oncogene, BCR-ABL. Tyrosine kinase activity of fusion protein BCR-ABL is the main cause of CML. Even if imatinib ... -
Çocukluk cağı lösemi tanılı hastalarda sitogenetik anomaliler
GİRİŞ ve AMAÇ: Konvansiyonel sitogenetik analiz, çocukluk çağında görülen akut lenfoblastik lösemi (ALL) ve akut myeloid lösemi (AML) hastalarında hem tanı hem de hastalık seyrinin izlenmesinde oldukça yol göstericidir. ... -
Determining the frequency of iron overload at diagnosis in de novo acute myeloid leukemia patients with multilineage dysplasia or myelodysplasia-related changes: a case control study
Yavuz, Boran; Aydın, Seda; Bozkurt, Sureyya; Üner, Ayşegül; Büyükaşık, Yahya (Springer Heidelberg, 2019)Acute myeloid leukemia (AML) with myelodysplasia-related changes (AML-MRC) is a new disease category, which was defined as a separate entity in the World Health Organization Classification of Tumours of Haematopoietic and ... -
Downregulation of stearoyl-CoA desaturase 1 (SCD-1) promotes resistance to imatinib in chronic myeloid leukemia
Günes, Buket Altınok; Hekmatshoar, Yalda; Özkan, Tülin; Bozkurt, Süreyya; Aydos, Oya Sena Erdoğan; Büyükaşık, Yahya; Aladağ, Elifcan; Asuman Sunguroğlu (Mattioli 1885, 2022)Chronic myeloid leukemia (CML) is a malignant hematopoietic stem cell disease resulting in the fusion of BCR and ABL genes and characterized by the presence of the reciprocal translocation t(9;22)(q34;q11). BCR-ABL, a ... -
Eksozomlar ve kanserdeki rolleri
Bozkurt, Süreyya (2018)Eksozomlar, vücutta bulunan hücrelerin neredeyse tamamı tarafından salgılanan, 40-100 nanometre (nm) çapında ve çift fosfolipid tabaka ile çevrili ekstrasellüler veziküllerdir. İçlerinde proteinler, lipitler, çok çeşitli ... -
First report of t(1;15)(q21;q11.2) and t(1;21)(q21;q11.2) anomalies in Burkitt Lymphoma
Bozkurt, Süreyya; Okay, Mufide; Haznedaroğlu, Celalettin İbrahim (KUWAIT MEDICAL ASSOC, 2021)Burkitt lymphoma (BL) is a highly aggressive B cell neoplasm characterized by t(8;14)(q24;q32) which involves the MYC gene. Sometimes, patients have additional cytogenetic anomalies beside t(8;14)(q24;q32) and these anomalies ... -
Hematological neoplastic disorders with chromosome 3 abnormalities
Bozkurt, Süreyya; Okay, Mufide; Sağlam, Filiz; Haznedaroğlu, Celalettin İbrahim (Carbone Editore, 2019)Introduction: Conventional karyotyping in the patients with haematological malignancies is very important. Because chromosomal abnormalities which detected in these patients have diagnostic and prognostic value. Aim: The ... -
MDA-MB-231 meme kanseri hücre dizisinde prostoglandin endoperoksid H sentaz 2 (PTGS2), kalretikulin (CALR) ve keratin-19 (KRT19) genlerinin transkripsiyon aşamasında anlatımlarının araştırılması
Bozkurt, Süreyya; Kaya Yiğit, Duygu (DergiPark, 2020)Bu çalışmada MDA-MB-231 meme kanser hücre hattında prostaglandin endoperoksid H sentaz 2 (PTGS2), kalretikulin (CALR) ve keratin-19 (KRT19) genlerinin transkripsiyon düzeyindeki gen anlatımlarının belirlenmesi amaçlanmış ... -
New mutations in KCNT2 gene causing early infantile epileptic encephalopathy type 57: Case study and literature review
Purpose: Early infantile epileptic encephalopathy (EIEE) 57 belongs to a group of encephalopathies with early-onset and characterised by severe electroencephalogram abnormalities, seizures, developmental delay and intellectual ... -
The novel translocation of t (1;21) in multiple myeloma with poor prognosis
Okay, Mufide; Bozkurt, Süreyya; Özgeyik, Mehmet; Haznedaroğlu, İbrahim Celalettin (DergiPark, 2019)Objective: Multiple myeloma (MM) is characterized as the neoplastic proliferation of plasma cells producing a monoclonal paraprotein. The aim of this paper is to report complex karyotype that leads to a fatal clinical ... -
Rare cytogenetic anomalies in two pediatric patients with acute leukemia
Bozkurt, Süreyya; Ünal, Şule; Bayhan, Turan; Gümrük, Fatma; Çetin, Mualla (Galenos Yayincilik, 2020)Structural chromosomal abnormalities are frequently seen in both pediatric acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) cases [1,2,3]. Although some chromosomal abnormalities are common, other ...
