Browsing by Author "Dere, Egemen"
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Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines
Tunc, Duygu; Dere, Egemen; Karakas, Didem; Cevatemre, Buse; Yilmaz, Veysel Turan; Ulukaya, Engin (Pergamon-Elsevier Science Ltd, 2017)Metal-based chemotherapeutics such as cisplatin are widely used treatment of lung cancer which is the major cause of cancer-related mortality worldwide. Recent studies demonstrated that novel metal-based compounds have ... -
Enhanced cytotoxic activity of doxorubicin through the inhibition of autophagy in triple negative breast cancer cell line
Aydinlik, Seyma; Erkisa, Merve; Cevatemre, Buse; Sarimahmut, Mehmet; Dere, Egemen; Ari, Ferda; Ulukaya, Engin (Elsevier Science Bv, 2017)Background: The outcome of triple negative breast cancer is still poor and requires improvement with better therapy options. Autophagy has recently been shown to play a role in anticancer drug resistance. Therefore, we ... -
Identification of microenvironmental regulation and therapeutic targeting of oncogenic eEF2K in pancreatic cancer
Karakaş Zeybek, Didem; Kahraman, Nermin; Bayraktar, Recep; Kabil, Nashwa; Ulukaya, Engin; Dere, Egemen; Berestein, Gabriel Lopez; Özpolat, Bülent (Wiley, 2019)Eukaryotic elongation factor 2 kinase (eEF2K) is overexpressed in cancer cells and its overexpression is correlated with poor prognosis in several types of cancer. It has been known that pancreatic cancer (PaCa) has a ... -
Identification of microenvironmental regulation and therapeutic targeting of ongenic EF-2 kinase in pancreatic cancer
Karakaş Zeybek, Didem; Kahraman, Nermin; Bayraktar, Recep; Kabil, Nashwa; Ulukaya, Engin; Dere, Egemen; Lopez-Berestein, Gabriel; Özpolat, Bülent (Science Direct, 2018)Introduction Pancreatic cancer (PaCa) is one of the most aggressive and deadliest cancer with 6 months average survival rate. Recent studies indicate that the tumour microenvironment (TME) plays an important role in all ... -
Induction of autophagy enhances apoptotic cell death via epidermal growth factor receptor inhibition by canertinib in cervical cancer cells
Aydinlik, Seyma; Dere, Egemen; Ulukaya, Engin (Elsevier, 2019)Background: It has been known epidermal growth factor receptor (EGFR) frequently overexpressed in cervical cancer. High levels of EGFR expression in their tumors leads to a poor prognosis and inhibition frequently induces ...
