Browsing by Author "Erbilgin, Yucel"
Now showing items 1-5 of 5
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Lymphoma predisposing gene in an extended family: CD70 signaling defect
Khodzhaev, Khusan; Bay, Sema Buyukkapu; Kebudi, Rejin; Altindirek, Didem; Kaya, Aysenur; Erbilgin, Yucel; Ng, Ozden Hatirnaz; Kiykim, Ayca; Erol Cipe, Funda; Sen Zengin, Feride; Firtina, Sinem; Ng, Yuk Yin; Aksoy, Basak Adakli; Sayitoglu, Muge (Springer/Plenum Publishers, 2020)Genome-wide sequencing studies in pediatric cancer cohorts indicate that about 10% of patients have germline mutations within cancer predisposition genes. Within this group, primary immune deficiencies take the priority ... -
Prognostic evidence of LEF1 isoforms in childhood acute lymphoblastic leukemia
Erbilgin, Yucel; Hatirnaz Ng, Ozden; Can, Ismail; Firtina, Sinem; Kucukcankurt, Fulya; Karaman, Serap (WILEY, 2021)Introduction: The lymphoid enhancer factor 1 (LEF1) is a DNA-binding transcription factor that functions in the Wnt signaling pathway. Increased LEF1 activity is associated with progression of several types of cancer ... -
Prognostic gene alterations and clonal changes in childhood B-ALL
Erbilgin, Yucel; Firtina, Sinem; Mercan, Sevcan; Ng, Ozden Hatirnaz; Karaman, Serap; Tasar, Orcun; Karakas Zeybek, Didem; Celkan, Tulin Tiraje; Zenging, Emine; Sarperg, Nazan; Yildirmak, Zeynep Yildiz; Sisko, Sinem; Ozbek, Ugur; Sayitoglu, Muge (Pergamon-Elsevier Science Ltd, 2019)Genomic profiles of leukemia patients lead to characterization of variations that provide the molecular classification of risk groups, prediction of clinical outcome and therapeutic decisions. In this study, we examined ... -
PTEN and AKT1 variations in childhood T-Cell acute lymphoblastic leukemia
Kucukcankurt, Fulya; Erbilgin, Yucel; Firtina, Sinem; Ng, Ozden Hatirnaz; Karakas, Zeynep; Celkan, Tiraje; Unuvar, Aysegul; Ozbek, Ugur; Sayitoglu, Muge (Galenos Yayincilik, 2020)Objective: PTEN/AKT pathway deregulations have been reported to be associated with treatment response in acute leukemia. This study examined pediatric T-cell acute lymphoblastic leukemia (T-ALL) samples for PTEN and AKT1 ... -
Zinc finger protein 384 ( ZNF384) impact on childhood mixed phenotype acute leukemia and B-cell precursor acute lymphoblastic leukemia
Sudutan, Tugce; Erbilgin, Yucel; Hatırnaz, Ozden; Karaman, Serap; Karakas, Zeynep; Kucukcankurt, Fulya; Celkan, Tiraje; Timur, Cetin; Ozdemir, Gul Nihal; Hacısalihoglu, Sadan; Aylan Gelen, Sema; Sayitoglu, Muge (Taylor and Francis, 2022)B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a heterogeneous malignancy and consists of several genetic abnormalities. Some of these abnormalities are used in clinics for risk calculation and treatment ...
