Browsing by Author "Erol Cipe, Funda"
Now showing items 1-18 of 18
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Biallelic form of a known CD3E mutation in a patient with severe combined immunodeficiency
Erman, Baran; Firtina, Sinem; Fisgin, Tunc; Bozkurt, Ceyhun; Erol Cipe, Funda (Springer/Plenum Publishers, 2020)T cell receptor (TCR) complex consists of αβ or γδ TCR chains in combination with four CD3 subunits, CD3ε, CD3γ, CD3δ, and CDζ [1]. This complex is required for thymocyte development and the initiation of T cell-mediated ... -
Comparison of allogeneic stem cell transplantation results from related or unrelated donors in beta-thalassemia major
Aydogdu, Selime; Mergen, Azize; Adakli Aksoy, Basak; Cokluk, Mila N.; Dikme, Gurcan; Erol Cipe, Funda; Fisgin, Tunc; Bozkurt, Ceyhun (Nature Publishing Group, 2019)Although there have been significant improvements with conventional therapies in beta thalassemia major, hematopoietic stem cell transplantation is only curative therapy. Related donors are preferred to diminish ... -
Comparison of hematopoietic stem cell transplantation results in patients with β-thalassemia major from three different graft types
Aydogdu, Selime; Toret, Ersin; Adakli Aksoy, Basak; Aydin, Muhammed Fatih; Erol Cipe, Funda; Bozkurt, Ceyhun; Fisgin, Tunc (Taylor & Francis Online, 2021)Allogeneic hematopoietic stem cell transplantation (HSCT) is the curative therapy for β-thalassemias that induces severe life-threatening complications. The human leukocyte antigen (HLA) registries and umbilical cord blood ... -
Comparison of turkish stem cell coordination center (TURKOK) with Istanbul university bone marrow bank (TRIS); A single center experience in match unrelated donors
Mergen, Azize; Aydogdu, Selime; Adakli Aksoy, Basak; Savci, Yunus Emre; Dikme, Gurcan; Erol Cipe, Funda; Bozkurt, Ceyhun; Fisgin, Tunc (Nature Publishing Group, 2019)Match family donors are the preferable options in allogenic stem cell transplant. However, in the absence of donor relatives match unrelated donors have been an option. In this study, the donor screening, transplant ... -
Could the COVID-19 infection have a better prognosis than expected in pediatric hematology oncology and bone marrow transplant patients?
Oner, Ozlem Basoglu; Aksoy, Basak Adakli; Yaman, Ayhan; Sutcu, Murat; Cipe, Funda; Atca, Ali Onder; Bozkurt, Ceyhun; Fisgin, Tunc (AVES, 2021)Coronavirus disease 2019 (COVID-19) is a pandemic that spread rapidly worldwide (1). So far, very few reports concerning the impact of COVID-19 among patients with pediatric hematologic-oncologic diseases are available ... -
Donor lymphocyte infusion administrations after allogeneic stem cell transplantations in pediatrics: a single center experience
Aydogdu, Selime; Mergen, Azize; Adakli Aksoy, Basak; Akbay, Hazal S.; Erol Cipe, Funda; Dikme, Gurcan; Fisgin, Tunc; Bozkurt, Ceyhun (Nature Publishing Group, 2019)Loss of chimerism is one of the major problems after allogeneic stem cell transplantation(SCT). Donor- lymphocyte infusions(DLI) are used as a treatment after taper or stopping immunosuppression. In this study, DLI ... -
Extended clinical and immunological phenotype and transplant outcome in CD27 and CD70 deficiency
Ghosh, Sujal; Bal, Sevgi Köstel; Edwards, Emily S J; Pillay, Bethany; Jimenez-Heredia, Raúl; Rao, Geetha; Erol Cipe, Funda; Salzer, Elisabeth; Zoghi, Samaneh; Abolhassani, Hassan; Momen, Tooba; Gostick, Emma; Price, David A; Zhang, Yu; Oler, Andrew J; Gonzaga-Jauregui, Claudia; Erman, Baran; Metin, Ayse; Ilhan, Inci; Haskologlu, Sule; Islamoglu, Candan; Baskin, Kubra; Ceylaner, Serdar; Yilmaz, Ebru; Unal, Ekrem; Karakukcu, Musa; Berghuis, Dagmar; Cole, Theresa; Gupta, Aditya Kumar; Hauck, Fabian; Hoepelman, Andy; Baris, Safa; Karakoc-Aydiner, Elif; Ozen, Ahmet; Kager, Leo; Holzinger, Dirk; Paulussen, Michael; Krüger, Renate; Meisel, Roland; Oommen, Prasad Thomas; Morris, Emma C; Neven, Benedicte; Worth, Austen J J; Montfrans, Joris M van; Fraaij, Pieter; Choo, Sharon; Dogu, Figen; Davies, E Graham; Burns, Siobhan; Dueckers, Gregor; Becker, Ruy Perez; Bernuth, Horst von; Latour, Sylvain; Faraci, Maura; Gattorno, Marco; Su, Helen; Pan-Hammarström, Qiang; Hammarström, Lennart; Lenardo, Michael J; Ma, Cindy S; Niehues, Tim; Aghamohammadi, Asghar; Rezaei, Nima; Ikinciogullari, Aydan; Tangye, Stuart G; Lankester, Arjan C; Boztug, Kaan (2020)Biallelic mutations in the genes encoding CD27 or its ligand CD70 underlie inborn errors of immunity characterized predominantly by EBV-associated immune dysregulation, such as chronic viremia, severe infectious mononucleosis, ... -
Genetic screening of the patients with primary immunodeficiency by whole-exome sequencing
Erman, Baran; Erol Cipe, Funda (New Rochelle, 2020)Background: Primary immunodeficiencies (PIDs) are a heterogeneous group of congenital disorders characterized by susceptibility to recurrent infections, allergy, malignancies and autoimmunity. The identification of ... -
ILC3 deficiency and generalized ILC abnormalities in DOCK8-deficient patients
Eken, Ahmet; Cansever, Murat; Okus, Fatma Zehra; Erdem, Serife; Nain, Ercan; Azizoglu, Zehra Busra; Haliloglu, Yesim; Karakukcu, Musa; Ozcan, Alper; Devecioglu, Omer; Aksu, Guzide; Arikan Ayyildiz, Zeynep; Topal, Erdem; Karakoc Aydiner, Elif; Kiykim, Ayca; Metin, Ayse; Erol Cipe, Funda; Kaya, Aysenur; Artac, Hasibe; Reisli, Ismail; Guner, Sukru N.; Uygun, Vedat; Tezcan Karasu, Gulsun; Doenmez Altuntas, Hamiyet; Canatan, Halit; Oukka, Mohamed; Ozen, Ahmet; Chatila, Talal A.; Keles, Sevgi; Baris, Safa; Unal, Ekrem; Patiroglu, Turkan (Wiley, 2020)BackgroundDedicator of cytokinesis 8 (DOCK8) deficiency is the main cause of the autosomal recessive hyper-IgE syndrome (HIES). We previously reported the selective loss of group 3 innate lymphoid cell (ILC) number and ... -
Invasive saprochaete capitata Infection in a patient with autosomal recessive CARD9 deficiency and a review of the literature
Erman, Baran; Firtina, Sinem; Aksoy, Basak Adakli; Aydogdu, Selime; Genc, Gonca Erkose; Dogan, Oner; Bozkurt, Ceyhun; Fisgin, Tunc; Erol Cipe, Funda (Springer/Plenum Publishers, 2020)Purpose Autosomal recessive (AR) CARD9 deficiency is an inherited immune disorder which results in impaired innate immunity against various fungi. Superficial and invasive fungal infections, mainly caused by Candida or ... -
Lymphoma predisposing gene in an extended family: CD70 signaling defect
Khodzhaev, Khusan; Bay, Sema Buyukkapu; Kebudi, Rejin; Altindirek, Didem; Kaya, Aysenur; Erbilgin, Yucel; Ng, Ozden Hatirnaz; Kiykim, Ayca; Erol Cipe, Funda; Sen Zengin, Feride; Firtina, Sinem; Ng, Yuk Yin; Aksoy, Basak Adakli; Sayitoglu, Muge (Springer/Plenum Publishers, 2020)Genome-wide sequencing studies in pediatric cancer cohorts indicate that about 10% of patients have germline mutations within cancer predisposition genes. Within this group, primary immune deficiencies take the priority ... -
Mutational landscape of severe combined immunodeficiency patients from Turkey
Firtina, Sinem; Ng, Yuk Yin; Ng, Ozden Hatirnaz; Kiykim, Ayca; Aydiner, Elif; Nepesov, Serdar; Camcioglu, Yildiz; Sayar, Esra H.; Reisli, Ismail; Torun, Selda H.; Cogurlu, Tuba; Uygun, Dilara; Simsek, Isil E.; Kaya, Aysenur; Erol Cipe, Funda; Cagdas, Deniz; Yucel, Esra; Cekic, Sukru; Uygun, Vedat; Baris, Safa; Ozen, Ahmet; Ozbek, Ugur; Sayitoglu, Muge (Wiley, 2020)Severe combined immunodeficiency (SCID) has a diverse genetic aetiology, where a clinical phenotype, caused by single and/or multiple gene variants, can give rise to multiple presentations. The advent of next-generation ... -
A novel foxn1 variant is identified in two siblings with nude severe combined immunodeficiency
Firtina, Sinem; Erol Cipe, Funda; Ng, Yuk Yin; Kiykim, Ayca; Ng, Ozden Hatirnaz; Sudutan, Tugce; Aydogmus, Cigdem; Baris, Safa; Ozturk, Gulyuz; Aydiner, Elif; Ozen, Ahmet; Sayitoglu, Muge (Springer/Plenum Publishers, 2019)Severe combined immunodeficiency (SCID) is the most severe form of primary immunodeficiencies (PIDs) caused by gene variants that lead to a failure of functional T cell development, with or without accompanying defects ... -
Novel frameshift autosomal recessive loss-of-function mutation in SMARCD2 encoding a chromatin remodeling factor mediates granulopoiesis
Yucel, Esra Ozek; Karakus, Ibrahim Serhat; Krolo, Ana; Kiykim, Ayca; Heredia, Raul Jimenez; Tamay, Zeynep; Erol Cipe, Funda; Karakoc-Aydiner, Elif; Ozen, Ahmet; Karaman, Serap; Boztug, Kaan; Baris, Safa (2021)Purpose: Recently, a new form of congenital neutropenia that is caused by germline biallelic loss-of-function mutations in the SMARCD2 gene was described in four patients. Given the rarity of the condition, the clinical ... -
Primary immunodeficiencies: HSCT experiences of a single center in Turkey
Erol Cipe, Funda; Adakli Aksoy, Basak; Aydogdu, Selime; Dikme, Gurcan; Kiykim, Ayca; Aydogmus, Cigdem; Yucel, Esra; Bozkurt, Ceyhun; Fisgin, Tunc (WILEY, 2021)Background Primary immunodeficiency diseases (PID) are characterized by the occurrence of frequent infections and are caused by many genetic defects. Hematopoietic stem cell transplantation (HSCT) is the only curative ... -
A set of clinical and laboratory markers differentiates hyper-IgE syndrome from severe atopic dermatitis
Kasap, Nurhan; Celik. Velat; Isik, Sakine; Cennetoglu, Pakize; Kiykim, Ayca; Bilgic Eltan, Sevgi; Nain, Ercan; Ogulur, Ismail; Baser, Dilek; Akkelle, Emre; Celiksoy, Mehmet Halil; Kocamis, Burcu; Erol Cipe, Funda; Yucelten, Ayse Deniz; Karakoc Aydiner, Elif; Ozen, Ahmet; Baris, Safa (Elsevier Inc., 2021)Hyper-IgE syndrome (HIES) patients may share many features observed in severe atopic dermatitis (SAD), making a diagnostic dilemma for physicians. Determining clinical and laboratory markers that distinguish both disorders ... -
Single-center study of 72 patients with severe combined immunodeficiency: clinical and laboratory features and outcomes
Bayram, Ozlem; Haskoloǧlu, Şule; Bayrakoğlu, Deniz; Bal, Sevgi Köstel; İslamoğlu, Candan; Çipe, Funda Erol; Kendirli, Tanıl; Kurşun, Nazmiye (Springer, 2021)Abstract: Severe combined immunodeficiency is an inborn error of immunity characterized by impairments in the numbers and functions of T and B lymphocytes due to various genetic causes, and if it remains untreated, patients ... -
Stem cell transplantation for high-risk acute lymphoblastic leukemia in a developing country: a single-center experience
Bozkurt, C.; Aksoy, B.; Aydogdu, S.; Bozkurt, S.; Cipe, F.; Oner, O.; Ozsoy, S.; Fisgin, T. (WILEY, 2020): Allogeneic stem cell transplantation in patients with a diagnosis of high-risk acute lymphoblastic leukemia results in high rates of survival in developed countries. Our aim with this presentation was to share our ...
