Browsing by Author "Fışgın, Tunç"
Now showing items 1-14 of 14
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Assessment of serum vitamin D in pediatric hematopoietic stem cell transplantation patients and its relation with complications
Karakaş, Zeynep; Aydoğdu, Selime; Yılmaz, Yasin; Bozkurt, Ceyhun; Aykanat, Alper; Fışgın, Tunç (Nature Publishing Group, 2018)Recently, evaluation of serum vitamin D level in pediatric hematopoietic stem cell transplantation (HSCT) patients gained popularity, as there is close relation with development of GVHD and complications. Our aim was ... -
Beta globin mutations in Turkish, northern Iraqi and albanian patients with beta thalassemia major
Hançer, Veysel Sabri; Fışgın, Tunç; Büyükdoğan, Murat; Bozkurt, Ceyhun; Lako, Sotiraq (Pagepress Publ, 2018)The mutation detection of beta thalassemia is absolutely necessary for molecular diagnosis, as well as any genetic epidemiological study. The b globin gene has 3 exons and 2 introns, involved in beta-thalassemic pathogenesis. ... -
Biallelic form of a known CD3E mutation in a patient with severe combined immunodeficiency
Erman, Baran; Fırtına, Sinem; Fışgın, Tunç; Bozkurt, Ceyhun; Erol Cipe, Funda (Springer/Plenum Publishers, 2020)T cell receptor (TCR) complex consists of αβ or γδ TCR chains in combination with four CD3 subunits, CD3ε, CD3γ, CD3δ, and CDζ [1]. This complex is required for thymocyte development and the initiation of T cell-mediated ... -
Comparison of allogeneic stem cell transplantation results from related or unrelated donors in beta-thalassemia major
Aydoğdu, Selime; Mergen, Azize; Adaklı Aksoy, Başak; Çokluk, Mila N.; Dikme, Gürcan; Erol Cipe, Funda; Fışgın, Tunç; Bozkurt, Ceyhun (Nature Publishing Group, 2019)Although there have been significant improvements with conventional therapies in beta thalassemia major, hematopoietic stem cell transplantation is only curative therapy. Related donors are preferred to diminish ... -
Comparison of hematopoietic stem cell transplantation results in patients with β-thalassemia major from three different graft types
Aydoğdu, Selime; Töret, Ersin; Adaklı Aksoy, Başak; Aydın, Muhammed Fatih; Erol Cipe, Funda; Bozkurt, Ceyhun; Fışgın, Tunç (Taylor & Francis Online, 2021)Allogeneic hematopoietic stem cell transplantation (HSCT) is the curative therapy for β-thalassemias that induces severe life-threatening complications. The human leukocyte antigen (HLA) registries and umbilical cord blood ... -
Comparison of turkish stem cell coordination center (TURKOK) with Istanbul university bone marrow bank (TRIS); A single center experience in match unrelated donors
Mergen, Azize; Aydoğdu, Selime; Adaklı Aksoy, Başak; Savcı, Yunus Emre; Dikme, Gürcan; Erol Cipe, Funda; Bozkurt, Ceyhun; Fışgın, Tunç (Nature Publishing Group, 2019)Match family donors are the preferable options in allogenic stem cell transplant. However, in the absence of donor relatives match unrelated donors have been an option. In this study, the donor screening, transplant ... -
Could the COVID-19 infection have a better prognosis than expected in pediatric hematology oncology and bone marrow transplant patients?
Öner, Özlem Başoğlu; Aksoy, Başak Adaklı; Yaman, Ayhan; Sütçü, Murat; Cipe, Funda; Atça, Ali Önder; Bozkurt, Ceyhun; Fışgın, Tunç (AVES, 2021)Coronavirus disease 2019 (COVID-19) is a pandemic that spread rapidly worldwide (1). So far, very few reports concerning the impact of COVID-19 among patients with pediatric hematologic-oncologic diseases are available ... -
Donor lymphocyte infusion administrations after allogeneic stem cell transplantations in pediatrics: a single center experience
Aydoğdu, Selime; Mergen, Azize; Adaklı Aksoy, Başak; Akbay, Hazal S.; Erol Cipe, Funda; Dikme, Gürcan; Fışgın, Tunç; Bozkurt, Ceyhun (Nature Publishing Group, 2019)Loss of chimerism is one of the major problems after allogeneic stem cell transplantation(SCT). Donor- lymphocyte infusions(DLI) are used as a treatment after taper or stopping immunosuppression. In this study, DLI ... -
Extracorporeal photopheresis treatment for steroid resistant graft versus host disease in pediatrics: single center experience
Aksoy, Başak Adaklı; Savcı, Yunus Emre; Mergen, Azize; Aydoğdu, Selime; Dikme, Gürcan; Bozkurt, Ceyhun; Fışgın, Tunç (Nature Publishing Group, 2019)Background: Steroid resistant graft vs host disease (GVHD) is defined as unresolved or worsened symptomatology of GVHD at day 14 despite effective immunosuppression with steroid therapy. Second line immunosuppressive agents, ... -
Hit three birds with one stone: successful stem cell transplantation from one family donor to three siblings
Aksoy, Başak Adaklı; Aydoğdu, Selime; Dikme, Gürcan; Mergen, Azize; Bozkurt, Ceyhun; Fışgın, Tunç (Nature Publishing Group, 2019)Background: Thalassemia major is a single gene related hereditary hemoglobinopaty required life long regular transfusions with chelation therapies. Stem cell transplantation is the only curative treatment of the disease. ... -
Invasive saprochaete capitata Infection in a patient with autosomal recessive CARD9 deficiency and a review of the literature
Erman, Baran; Fırtına, Sinem; Aksoy, Başak Adaklı; Aydoğdu, Selime; Genç, Gonca Erköse; Doğan, Öner; Bozkurt, Ceyhun; Fışgın, Tunç; Erol Cipe, Funda (Springer/Plenum Publishers, 2020)Purpose Autosomal recessive (AR) CARD9 deficiency is an inherited immune disorder which results in impaired innate immunity against various fungi. Superficial and invasive fungal infections, mainly caused by Candida or ... -
Primary immunodeficiencies: HSCT experiences of a single center in Turkey
Erol Cipe, Funda; Adaklı Aksoy, Başak; Aydoğdu, Selime; Dikme, Gürcan; Kıykım, Ayca; Aydoğmus, Çiğdem; Yücel, Esra; Bozkurt, Ceyhun; Fışgın, Tunç (WILEY, 2021)Background Primary immunodeficiency diseases (PID) are characterized by the occurrence of frequent infections and are caused by many genetic defects. Hematopoietic stem cell transplantation (HSCT) is the only curative ... -
Prognostic factors for survival in children who relapsed after allogeneic hematopoietic stem cell transplantation for acute leukemia
Hazar, Volkan; Tezcan Karasu, Gülsün; Öztürk, Gülyüz; Küpesiz, Alphan; Aksoylar, Serap; Özbek, Namık; Uygun, Vedat; İleri, Talia; Okur, Fatma Visal; Koçak, Ülker; Çakı Kılıç, Suar; Akçay, Arzu; Güler, Elif; Kansoy, Savaş; Karakükcü, Musa; Bayram, İbrahim; Aksu , Tekin; Yeşilipek, Akif; Karagün, Barbaros Şahin; Yılmaz, Şebnem; Ertem, Mehmet; Uçkan, Duygu; Fışgın, Tunç; Gürsel, Orhan; Yaman, Yöntem; Bozkurt, Ceyhun; Gökçe, Müge (2020)Background: Post-transplant relapse has a dismal prognosis in children with acute leukemia undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Data on risk factors, treatment options, and outcomes ... -
The use of allogeneic mesenchymal stem cells in childhood steroid-resistant acute graft-versus-host disease: a retrospective study of a single-center experience
Bozkurt, Ceyhun; Karaöz, Erdal; Adaklı Aksoy, Başak; Aydoğdu, Selime; Fışgın, Tunç (Galenos Yayincilik, 2019)Objective: Steroid-resistant acute graft-versus-host disease (srAGVHD) is the most important cause of morbidity and mortality after allogeneic stem cell transplantation. There are several treatment methods available, ...
