Browsing by Author "Fael, Hanan"

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Pulmonary delivery of favipiravir in rats reaches high local concentrations without causing oxidative lung injury or sSystemic side effects

Akbal Dagistan, Ozlem; Sevim, Mustafa; Sen, Leyla Semiha; Basarir, Nur Sena; Culha, Meltem; Erturk, Aybige; Fael, Hanan; Kaptan, Engin; Sancar, Serap; Mulazimoglu Durmusoglu, Lutfiye; Yegen, Berrak C; Yildiz Pekoz, Ayca (MDPI, 2022)

Favipiravir displays a rapid viral clearance, a high recovery rate and broad therapeutic safety; however, its oral administration was associated with systemic side effects in susceptible patients. Considering that the ...
Pulmonary delivery of favipiravir inhalation solution for COVID-19 treatment: in vitro characterization, stability, in vitro cytotoxicity, and antiviral activity using real time cell analysis

Yildiz Pekoz, Ayca; Akbal Dagistan, Ozlem; Fael, Hanan; Culha, Meltem; Erturk, Aybige (TAYLOR & FRANCIS, 2022)

Favipiravir, an RNA-dependent RNA polymerase (RdRp) inhibitor, is used to treat patients infected with influenza virus and most recently with SARS-CoV-2. However, poor accumulation of favipiravir in lung tissue following ...