Browsing by Author "Hushmandi, Kiavash"
Now showing items 1-17 of 17
-
Cervical cancer progression is regulated by SOX transcription factors: Revealing signaling networks and therapeutic strategies
Paskeh, Mahshid Deldar Abad; Mirzaei, Sepideh; Gholami, Mohammad Hossein; Zarrabi, Ali; Zabolian, Amirhossein; Hashemi, Mehrdad; Hushmandi, Kiavash (Elsevier Science, 2021)Cervical cancer is the fourth common gynecologic cancer and is considered as second leading cause of death among women. Various strategies are applied in treatment of cervical cancer including radiotherapy, chemotherapy ... -
Chitosan-based nanoscale systems for doxorubicin delivery: Exploring biomedical application in cancer therapy
Ashrafizadeh, Milad; Hushmandi, Kiavash; Mirzaei, Sepideh; Bokaie, Saied; Bigham, Ashkan; Makvandi, Pooyan; Rabiee, Navid; Thakur, Vijay Kumar; Kumar, Alan Prem; Sharifi, Esmaeel; Varma, Rajender S.; Aref, Amir Reza; Wojnilowicz, Marcin; Zarrabi, Ali; Karimi-Maleh, Hassan; Voelcker, Nicolas H.; Mostafavi, Ebrahim; Orive, Gorka (AICHE Online Library, 2022)Green chemistry has been a growing multidisciplinary field in recent years showing great promise in biomedical applications, especially for cancer therapy. Chitosan (CS) is an abundant biopolymer derived from chitin and ... -
Correction: The long and short non-coding RNAs modulating EZH2 signaling in cancer (Journal of Hematology & Oncology, (2022), 15, 1, (18), 10.1186/s13045-022-01235-1)
Mirzaei, Sepideh; Gholami, Mohammad Hossein; Hushmandi, Kiavash; Hashemi, Farid; Zabolian, Amirhossein; Canadas, Israel; Zarrabi, Ali; Nabavi, Noushin; Aref, Amir Reza; Crea, Francesco; Wang, Yuzhuo; Ashrafizadeh, Milad; Kumar, Alan Prem (BioMed Central Ltd, 2022)The original article [1] contained an error in co-author, Farid Hashemi’s name which has since been corrected. © 2022, The Author(s). -
Doxorubicin-loaded graphene oxide nanocomposites in cancer medicine: stimuli-responsive carriers, co-delivery and suppressing resistance
Ashrafizadeh, Milad; Saebfar, Hamidreza; Gholami, Mohammad Hossein; Hushmandi, Kiavash; Zabolian, Amirhossein; Zarrabi, Ali (2022)Introduction: The application of doxorubicin (DOX) in cancer therapy has been limited due to its drug resistance and poor internalization. Graphene oxide (GO) nanostructures have the capacity for DOX delivery while promoting ... -
Gene regulation by antisense transcription: a focus on neurological and cancer diseases
Najaf, Sajad; Tan, Shing Cheng; Raee, Pourya; Rahmati, Yazdan; Asemani, Yahya; Lee, E. Hui Clarissa; Hushmandi, Kiavash; Aref, Amir Reza (Science Direct, 2022)Advances in high-throughput sequencing over the past decades have led to the identification of thousands of non-coding RNAs (ncRNAs), which play a major role in regulating gene expression. One emerging class of ncRNAs is ... -
The long and short non-coding RNAs modulating EZH2 signaling in cancer
Mirzaei, Sepideh; Gholami, Mohammad Hossein; Hushmandi, Kiavash; Hshemi, Farid; Zabolian, Amirhossein; Canadas, Israel; Zarrabi, Ali; Nabavi, Noushin; Aref, Amir Reza; Crea, Francesco; Wang, Yuzhuo; Ashrafizadeh, Milad; Kumar, Alan Prem (2022)Non-coding RNAs (ncRNAs) are a large family of RNA molecules with no capability in encoding proteins. However, they participate in developmental and biological processes and their abnormal expression affects cancer ... -
Long non-coding RNAs and exosomal incRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling
Entezari, Maliheh; Ghanbarirad, Maryam; Taheriazam, Afshin; Sadrkhanloo, Mehrdokht; Zabolian, Amirhossein; Shekhi Beig Goharrizi, Mohammad Ali; Hushmandi, Kiavash; Aref, Amir Reza; Ashrafizadeh, Milad; Zarrabi, Ali; Nabavi, Noushin; Rabiee, Navid; Hashemi, Mehrdad; Samarghandian, Saeed (Elsevier Science, 2022)Among the different kinds of tumors threatening human life, lung cancer is one that is commonly observed in both males and females. The aggressive behavior of lung cancer and interactions occurring in tumor microenvironment ... -
Long non-coding RNAs and exosomal lncRNAs: Potential functions in lung cancer progression, drug resistance and tumor microenvironment remodeling
Entezari, Maliheh; Ghanbarirad, Maryam; Taheriazam, Afshin; Sadrkhanloo, Mehrdokht; Zabolian, Amirhossein; Goharrizi, Mohammad Ali Shekhi Beig; Hushmandi, Kiavash; Aref, Amir Reza; Ashrafizadeh, Milad; Zarrabi, Ali; Nabavi, Noushin; Rabiee, Navid; Hashemi, Mehrdad; Samarghandian, Saeed (Elsevier, 2022)Among the different kinds of tumors threatening human life, lung cancer is one that is commonly observed in both males and females. The aggressive behavior of lung cancer and interactions occurring in tumor microenvironment ... -
Long noncoding RNAs: A novel insight in the leukemogenesis and drug resistance in acute myeloid leukemia
Kirtonia, Anuradha; Ashrafizadeh, Milad; Hushmandi, Kiavash; Zabolian, Amirhossein; Bejandi, Atefe K.; Rani, Reshma; Pandey, Amit K.; Baligar, Prakash; Kumar, Vinit; Das, Bhudev C.; Garg, Manoj (Wiley-Blackwell, 2021)Acute myeloid leukemia (AML) is a common hematological disorder with heterogeneous nature that resulted from blocked myeloid differentiation and an enhanced number of immature myeloid progenitors. During several decades, ... -
Molecular landscape of LncRNAs in prostate cancer: A focus on pathways and therapeutic targets for intervention
Mirzaei, Sepideh; Abad Paskeh, Mahshid Deldar; Okina, Elena; Gholami, Mohammad Hossein; Hushmandi, Kiavash; Hashemi, Mehrdad; Kalu , Azuma; Zarrabi, Ali; Nabav, Noushin; Rabiee, Navid; Sharifi, Esmaeel; Karimi-Maleh, Hassan; Ashrafizadeh, Milad; Kumar, Alan Prem; Wang, Yuzhuo (PMC, 2022)Background: One of the most malignant tumors in men is prostate cancer that is still incurable due to its heterog‑ enous and progressive natures. Genetic and epigenetic changes play signifcant roles in its development. ... -
NF-κB as a regulator of cancer metastasis and therapy response: A focus on epithelial-mesenchymal transition
Mirzaei , Sepideh; Saghari, Sam; Bassiri, Farzaneh; Raesi, Rasoul; Zarrabi, Ali; Hushmandi, Kiavash; Sethi, Gautam; Tergaonkar, Vinay (Wiley, 2022)Metastasis of tumor cells is a complex challenge and significantly diminishes theoverall survival and prognosis of cancer patients. The epithelial‐to‐mesenchymaltransition (EMT) is a well‐known mechanism responsible for ... -
Non-coding RNAs and macrophage interaction in tumor progression
Entezari, Maliheh; Sadrkhanloo, Mehrdokht; Rashidi, Mohsen; Asnaf, Sholeh Etehad; Taheriazam, Afshin; Hashemi, Mehrdad; Ashrafizadeh, Milad; Zarrabi, Ali; Rabiee, Navid; Hushmandi, Kiavash; Mirzaei, Sepideh; Sethi, Gautam (Elsevier Ireland Ltd, 2022)The macrophages are abundantly found in TME and their M2 polarization is in favor of tumor malignancy. On the other hand, non-coding RNAs (ncRNAs) can modulate macrophage polarization in TME to affect cancer progression. ... -
Non-coding RNAs targeting notch signaling pathway in cancer : from proliferation to cancer therapy resistance
Hashemi, Mehrdad; Hasani, Sahar; Hajimazdarany, Shima; Mirmazloomi, Seyed Reza; Makvandy, Sara; Zabihi, Abbas; Goldoost, Yeganeh; Gholinia, Nazanin; Kakavand, Amirabbas; Tavakolpournegari, Alireza; Salimimoghadam, Shokooh; Nabavi, Noushin; Zarrabi, Ali; Taheriazam, Afshin; Entezari, Maliheh; Hushmandi, Kiavash (Elsevier B.V., 2022)Cancer is a challenging to treat disease with a high mortality rate worldwide, nevertheless advances in science has led to a decrease in the number of death cases caused by cancer. Aberrant expression of genes occurs during ... -
Noncoding RNAs and their therapeutics in paclitaxel chemotherapy: Mechanisms of initiation, progression, and drug sensitivity
Mahabady, Mahmood K.; Mirzaei, Sepideh; Saebfar, Hamidreza; Gholami, Mohammad H.; Zabolian, Amirhossein; Hushmandi, Kiavash; Hashemi, Farid; Tajik, Fatemeh; Hashemi, Mehrdad; Kumar, Alan P.; Aref, Amir R.; Zarrabi, Ali; Khan, Haroon; Hamblin, Michael R.; Ertas, Yavuz Nuri; Samarghandian, Saeed (Wiley, 2022)The identification of agents that can reverse drug resistance in cancer chemotherapy, andenhance the overall efficacy is of great interest. Paclitaxel (PTX) belongs to taxane family hat exerts an antitumor effect by ... -
Overcoming doxorubicin resistance in cancer: siRNA-loaded nanoarchitectures for cancer gene therapy
Deldar Abad Paskeh, Mahshid; Saebfar, Hamidreza; Mahabady, Mahmood Khaksary; Orouei, Sima; Hushmandi, Kiavash; Zarrabi, Ali (2022)Gene therapy can be used as a cancer therapy by affecting signaling networks participating in the aggressive behavior of tumors. Small interfering RNA (siRNA) is a genetic tool employed for gene silencing. The siRNA molecules ... -
Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches
Ashrafizadeh, Milad; Delfi, Masoud; Zarrabi, Ali; Sharifi, Esmaeel; Rabiee, Navid; Paiva-Santos, Ana Cláudia; Kumar, Alan Prem; Hushmandi, Kiavash; Nazarzadeh Zare, Ehsan; Makvandi, Pooyan (Elsevier, 2022)The site-specific delivery of antitumor agents is of importance for providing effective cancer suppression. Poor bioavailability of anticancer compounds and the presence of biological barriers prevent their accumulation ... -
Targeting AMPK signaling in ischemic/reperfusion injury: From molecular mechanism to pharmacological interventions
Paskeh, Mahshid Deldar Abad; Asadi, Ava; Mirzaei, Sepideh; Hashemi, Mehrdad; Entezari, Maliheh; Raesi, Rasoul; Hushmandi, Kiavash; Zarrabi, Ali; Ertas, Yavuz Nuri; Aref, Amir Reza; Samarghandian, Saeed; Reiter, Russel J; Ren, Jun (2022)Ischemia is a pathological process in which blood supply to a particular organ is temporarily interrupted resulting in disturbed biological function and homeostasis of local tissues. Following ischemia, reperfusion and ...
