Browsing by Author "Karakaş Zeybek, Didem"
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Cancer stem cells : root of the evil
Erkisa Genel, Merve; Karakaş Zeybek, Didem; Ulukaya, Engin (Begell House Inc., 2019)Cancer stem cells (CSCs) have been one of the most attractive research areas over the last two decades due to their important roles in aggressive tumor behaviors. Although CSCs are usually a small subpopulation of tumors ... -
Dual suppressive effect of miR-34a on the FOXM1/eEF2-kinase axis regulates triple-negative breast cancer growth and invasion
Bayraktar, Recep; Ivan, Cristina; Bayraktar, Emine; Kanlıkılıçer, Pınar; Kabil, Nashwa N.; Kahraman, Nermin; Mokhlis, Hamada A.; Karakaş Zeybek, Didem; Rodriguez-Aguayo, Cristian; Arslan, Ahmet; Sheng, Jianting; Wong, Stephen; Lopez-Berestein, Gabriel; Calin, George A.; Özpolat, Bülent (Amer Assoc Cancer Research, 2018)Purpose: Recent studies indicated that dysregulation of noncoding KNAs (ncRNA) such as miRNAs is involved in pathogenesis of various human cancers. However, the molecular mechanisms underlying miR-34a are not fully understood ... -
Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target
Karakaş Zeybek, Didem; Özpolat, Bülent (Springer Heidelberg, 2020)Eukaryotic elongation factor-2 kinase (eEF2K), an atypical member of alpha-kinase family, is highly overexpressed in breast, pancreatic, brain, and lung cancers, and associated with poor survival in patients. eEF2K promotes ... -
Identification of microenvironmental regulation and therapeutic targeting of oncogenic eEF2K in pancreatic cancer
Karakaş Zeybek, Didem; Kahraman, Nermin; Bayraktar, Recep; Kabil, Nashwa; Ulukaya, Engin; Dere, Egemen; Berestein, Gabriel Lopez; Özpolat, Bülent (Wiley, 2019)Eukaryotic elongation factor 2 kinase (eEF2K) is overexpressed in cancer cells and its overexpression is correlated with poor prognosis in several types of cancer. It has been known that pancreatic cancer (PaCa) has a ... -
Identification of microenvironmental regulation and therapeutic targeting of ongenic EF-2 kinase in pancreatic cancer
Karakaş Zeybek, Didem; Kahraman, Nermin; Bayraktar, Recep; Kabil, Nashwa; Ulukaya, Engin; Dere, Egemen; Lopez-Berestein, Gabriel; Özpolat, Bülent (Science Direct, 2018)Introduction Pancreatic cancer (PaCa) is one of the most aggressive and deadliest cancer with 6 months average survival rate. Recent studies indicate that the tumour microenvironment (TME) plays an important role in all ... -
The MTT viability assay yields strikingly false-positive viabilities although the cells are killed by some plant extracts
Karakaş Zeybek, Didem; Arı, Ferda; Ulukaya, Engin (Tubitak Scientific & Technical Research Council Turkey, 2017)The MTT assay is one of the often used cell viability/cytotoxicity assays. However, when the methanol extracts of plants are used to test their cytotoxic potential, interference may occur, resulting in false-positive ... -
Prognostic gene alterations and clonal changes in childhood B-ALL
Erbilgin, Yücel; Fırtına, Sinem; Mercan, Sevcan; Ng, Özden Hatırnaz; Karaman, Serap; Taşar, Orçun; Karakaş Zeybek, Didem; Celkan, Tulin Tiraje; Zengin, Emine; Sarper, Nazan; Yildirmak, Zeynep Yildiz; Şişko, Sinem; Özbek, Uğur; Sayitoğlu, Müge (Pergamon-Elsevier Science Ltd, 2019)Genomic profiles of leukemia patients lead to characterization of variations that provide the molecular classification of risk groups, prediction of clinical outcome and therapeutic decisions. In this study, we examined ... -
A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer
Cevatemre, Buse; Erkısa Genel, Merve; Aztopal, Nazlıhan; Karakaş Zeybek, Didem; Alper, Pınar; Tsimplouli, Chrisiida; Sereti, Evangelia; Dimas, Konstantinos; Armutak, Elif I. İkitimur; Gürevin, Ebru Gürel; Üvez, Ayça; Mori, Mattia; Berardozzi, Simone; Ingallina, Cinzia; D'Acquarica, Ilaria; Botta, Bruno; Özpolat, Bülent; Ulukaya, Engin (Academic Press Ltd- Elsevier Science Ltd, 2018)Several natural products have been suggested as effective agents for the treatment of cancer. Given the important role of CSCs (Cancer Stem Cells) in cancer, which is a trendy hypothesis, it is worth investigating the ... -
Synthesis and investigation of cytotoxicity of new N- and S,S-substituted-1,4-naphthoquinone (1,4-NQ) derivatives on selected cancer lines
Gökmen, Zeliha; Onan, Mehmet Erdi; Deniz, Nahide Gülşah; Karakaş Zeybek, Didem; Ulukaya, Engin (Taylor & Francis Inc, 2019)1,4-Naphthoquinones (1,4-NQ) have been reported to possess a variety of pharma-cological properties including antibacterial, antifungal, antiviral, anti-inflammatory, anti-artherosclerotic, and anticancer effects. In this ... -
Tumor chemosensitivity assays are helpful for personalized cytotoxic treatments in cancer patients
Ulukaya, Engin; Karakaş, Didem; Dimas, Konstantinos (MDPI, 2021)Tumor chemosensitivity assays (TCAs), also known as drug response assays or individualized tumor response tests, have been gaining attention over the past few decades. Although there have been strong positive correlations ... -
Unfolded Protein Response is Involved in Trans-Platinum (II) Complex-Induced Apoptosis in Prostate Cancer Cells via ROS Accumulation
Karakaş Zeybek, Didem; Cevatemre, Buse; Oral, Arzu Y.; Yılmaz, Veysel T.; Ulukaya, Engin (Bentham Science Publ Ltd, 2019)Background: Prostate cancer is one of the most common cancer types and it is the sixth leading cause of cancer-related death in men worldwide. Even though novel treatment modalities have been developed, it still a ...
