Browsing by Author "Karaman, Serap"
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Does growth hormone therapy enlarge pituitary adenomas?
Bitkin Celebi, Eda; Kara, Cengiz; Karaman, Serap; Basaranoglu, Murat; Yokus, Adem; Tuncer, Oguz (Galenos Publishing House, 2022)Objective: Pituitary adenomas are detected incidentally in some cases of childhood growth hormone deficiency. Growth hormones may affect tumor growth. This study analyzed the reliability of growth hormone therapy in patients ... -
Novel frameshift autosomal recessive loss-of-function mutation in SMARCD2 encoding a chromatin remodeling factor mediates granulopoiesis
Yucel, Esra Ozek; Karakus, Ibrahim Serhat; Krolo, Ana; Kiykim, Ayca; Heredia, Raul Jimenez; Tamay, Zeynep; Erol Cipe, Funda; Karakoc-Aydiner, Elif; Ozen, Ahmet; Karaman, Serap; Boztug, Kaan; Baris, Safa (2021)Purpose: Recently, a new form of congenital neutropenia that is caused by germline biallelic loss-of-function mutations in the SMARCD2 gene was described in four patients. Given the rarity of the condition, the clinical ... -
Prognostic evidence of LEF1 isoforms in childhood acute lymphoblastic leukemia
Erbilgin, Yucel; Hatırnaz Ng, Özden; Can, İsmail; Fırtına, Sinem; Küçükcankurt, Fulya; Karaman, Serap (WILEY, 2021)Introduction: The lymphoid enhancer factor 1 (LEF1) is a DNA-binding transcription factor that functions in the Wnt signaling pathway. Increased LEF1 activity is associated with progression of several types of cancer ... -
Prognostic gene alterations and clonal changes in childhood B-ALL
Erbilgin, Yücel; Fırtına, Sinem; Mercan, Sevcan; Ng, Özden Hatırnaz; Karaman, Serap; Taşar, Orçun; Karakaş Zeybek, Didem; Celkan, Tulin Tiraje; Zengin, Emine; Sarper, Nazan; Yildirmak, Zeynep Yildiz; Şişko, Sinem; Özbek, Uğur; Sayitoğlu, Müge (Pergamon-Elsevier Science Ltd, 2019)Genomic profiles of leukemia patients lead to characterization of variations that provide the molecular classification of risk groups, prediction of clinical outcome and therapeutic decisions. In this study, we examined ... -
Zinc finger protein 384 ( ZNF384) impact on childhood mixed phenotype acute leukemia and B-cell precursor acute lymphoblastic leukemia
Sudutan, Tuğce; Erbilgin, Yücel; Hatırnaz, Özden; Karaman, Serap; Karakaş, Zeynep; Küçükcankurt, Fulya; Celkan, Tülin Tiraje; Timur, Çetin; Özdemir, Gül Nihal; Hacısalihoglu, Sadan; Aylan Gelen, Sema; Sayitoğlu, Müge (Taylor and Francis, 2022)B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is a heterogeneous malignancy and consists of several genetic abnormalities. Some of these abnormalities are used in clinics for risk calculation and treatment ...
