Browsing by Author "Karaoz, Erdal"
Now showing items 1-20 of 52
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Age-related changes in the immunomodulatory effects of human dental pulp derived mesenchymal stem cells on the CD4 + T cell subsets
Ozdemir, Rabia Bilge Ozgul; Ozdemir, Alper Tunga; Kirmaz, Cengiz; Sariboyaci, Ayla Eker; Karaoz, Erdal; Erman, Gulay; Vatansever, H Seda; Gökmen, Nihal Mete (2021)Mesenchymal stem cells (MSCs) are powerful immunomodulatory cells. The effects of the aging on these abilities of MSCs have not been adequately clarified. In this study, alterations in immunomodulatory abilities of MSCs ... -
Calvarial bone defects in ovariectomised rats treated with mesenchymal stem cells and demineralised freeze-dried bone allografts
Kadiroglu, Ela Tules; Akbalik, Mehmet Erdem; Karaoz, Erdal; Kanay, Berna Ersoz; Dag, Ahmet; Ketani, Muzaffer Aydın; Eroglu, E. G.; Uysal, Ersin; Tuncer, Cudi M. (NLM (Medline), 2020)BACKGROUND: The aim of the study was to investigate the ability of a combination of bone marrow mesenchymal stem cells (BM-MSCs) with and without demineralised freeze-dried bone allografts (DFDBAs) to induce bone regeneration ... -
Can Wharton jelly derived or adipose tissue derived mesenchymal stem cell can be a treatment option for duchenne muscular dystrophy? answers as transcriptomic aspect
Sun Gungorurler, Eda; Karaoz, Erdal (2020)Introduction: Mesenchymal stem cells (MSCs) are able to differentiate into several cell lineages including skeletal muscle. In addition to their differentiation capacities, they have the ability to transfer their content ... -
Cardiovascular changes in WAG/Rij rats with genetic absence epilepsy: effects of chronic ethosuximide treatment
Sahin, Tugce Demirtas; Utkan, Tijen; Karson, Ayse; Yazir, Yusufhan; Karaoz, Erdal (CUKUROVA UNIV, 2020)Purpose: The aim of this study was to investigate the effects of chronic ethosuximide (ETX) treatment on absence seizures and cardiovascular parameters in WAG/Rij rats with genetic absence epilepsy. Materials and Methods: ... -
Comparative analyses of immunosuppressive characteristics of bone-marrow, wharton's jelly, and adipose tissue-derived human mesenchymal stem cells
Karaöz, Erdal; Demircan, Pinar Cetinalp; Erman, Gulay; Sun Gungorurler, Eda; Sariboyaci, Ayla Eker (Galenos Yayincilik, 2017)Objective: Mesenchymal stem cells (MSCs), which possess immunosuppressive characteristics on induced T-cells, were shown to be applicable in prevention and treatment of graft-versus-host disease. However, knowledge of ... -
Comparative proteomics analysis of four commonly used methods for identification of novel plasma membrane proteins
Yoneten, Kubra Karaosmanoglu; Kasap, Murat; Akpinar, Gurler; Kanli, Aylin; Karaoz, Erdal (Springer, 2019)Plasma membrane proteins perform a variety of important tasks in the cells. These tasks can be diverse as carrying nutrients across the plasma membrane, receiving chemical signals from outside the cell, translating them ... -
Comparison of different sources of mesenchymal stem cells: palatal versus lipoaspirated adipose tissue
Hakki, Sema S.; Turac, Gizem; Bozkurt, S. Buket; Kayis, Seyit Ali; Hakki, Erdogan E.; Sahin, Eren; Subasi Demir, Cansu; Karaoz, Erdal (Karger, 2017)Objectives: The purpose of this study was to compare the proliferation and differentiation potential of mesenchymal stem cells (MSCs) derived from palatal adipose tissue (PAT) and lipoaspirated adipose tissue (LAT). Materials ... -
Comparison of mesenchymal stem cell sheets and chondrocyte sheets in a rabbit growth plate injury model
Gultekin, Alper; Agirdil, Yucel; Duman, Busra Oncel; Subasi Demir, Cansu; Karaoz, Erdal (Tubitak Scientific & Technical Research Council Turkey, 2020)Background/aim: The treatment of posttraumatic deformities and differences in length between the extremities resulting from physeal injury remains controversial. The aims of this study were to compare the efficacy of ... -
Comparison of similar cells: mesenchymal stromal cells and fibroblasts
Ugurlu, Burcu; Karaoz, Erdal (Elsevier GmbH, 2020)Almost from all organs, both mesenchymal stromal cells and fibroblasts can be isolated. Mesenchymal stromal cells (MSCs) are the most preferred cellular therapeutic agents with the regenerative potential, and fibroblasts ... -
Contribution of bone marrow–derived mesenchymal stem cells to healing of pulmonary contusion-created rats
Demir, Sabri; Erturk, Ahmet; Gunal, Yasemin Dere; Ozmen, Ismail; Zengin, Mehmet; Yildiz, Dincer; Karaoz, Erdal; Karahan, Siyami; Senel, Emrah (Academic Press Inc., 2021)Background: The most common thoracic injury in children, resulting in trauma, is pulmonary contusion (PC). Bone marrow–derived mesenchymal stem cells (BM-MSCs) are used in wound healing and many other diseases. This study ... -
Determination of antibiotic impurities in good manufacturing practices-grade cell therapy medicinal products
Oztel, Olga Nehir; Korkmaz, Seval; Karaoz, Erdal (Taylor & Francis Inc, 2020)Backrounds: According to the regulations of the health autorities, cell-based therapy products must be manufactured in good manufacturing production (GMP) facilities, fulfilling the required GMP standards. Products developed ... -
Differentiation potential and tumorigenic risk of rat bone marrow stem cells are affected by long-term in vitro expansion
Karaoz, Erdal; Tepekoy Ozcelik, Filiz (Galenos Yayincilik, 2019)Objective: Mesenchymal stem cells (MSCs) have the capacity for extensive expansion and adipogenic, osteogenic, chondrogenic, myogenic, and neural differentiation in vitro. The aim of our study was to determine sternness, ... -
Effect of bone marrow and adipose tissue-derived mesenchymal stem cells on the natural course of corneal scarring after penetrating injury
Demirayak, Bengi; Yuksel, Nursen; Celik, Onur Sinan; Subasi, Cansu; Duruksu, Gokhan; Unal, Z. Seda; Yildiz, Demir Kursat; Karaoz, Erdal (Academic Press Ltd- Elsevier Science Ltd, 2016)In the present study, we investigate and compare the efficacy of bone marrow- and adipose tissue-derived mesenchymal stem cell (MSCs) in corneal wound healing. A penetrating injury was created in the right corneas of Wistar ... -
The effect of Korean red ginseng on mesenchymal stem cells from healthy and osteoporotic human bone marrow
Background: Osteoporosis is a disease characterized by an increase in bone fragility as a result of decreased bone mass and weakening of the bone structure. There are studies on the relationship between osteoporosis and ... -
The effect of recombinant tyrosine hydroxylase expression on the neurogenic differentiation potency of mesenchymal stem cells
Turac, Gizem; Duruksu, Gokhan; Karaoz, Erdal (Korean Spinal Neurosurgery Soc, 2018)Objective: Tyrosine hydroxylase (TH) is a rate-limiting enzyme in dopamine synthesis, making the enhancement of its activity a target for ensuring sufficient dopamine levels. Rat bone marrow mesenchymal stem cells (rBM-MSCs) ... -
The effect of umbilical cord-derived mesenchymal stem cell transplantation in a patient with cerebral palsy: a case report
Okur, Sibel Caglar; Erdogan, Sinan; Subasi Demir, Cansu; Gunel, Gulsen; Karaoz, Erdal (Korean Soc Stem Cell Research, 2018)Background: Cerebral Palsy (CP) is the most common motor disability reason of childhood that occurs secondarily to non-progressive damage in the brain whose development is still ongoing. Methods: 6-year-old dystonic-spastic ... -
Effects of VEGF plus adipose tissue derived mesenchymal stem cells with platelet rich plasma on inbred rat ovarian functions in premature ovarian insufficiency model
Vural, B.; Duruksu, G.; Vural, F.; Gorguc, M.; Karaoz, Erdal (Oxford Univ Press, 2017)What is known already: Numerous studies have found an increased risk of congenital malformations among live-born children conceived after assisted reproduction compared with spontaneously conceivedchildren. The underlying ... -
Effects of VEGF(+) mesenchymal stem cells and platelet-rich plasma on inbred rat ovarian functions in cyclophosphamide-induced premature ovarian insufficiency model
Vural, Birol; Duruksu, Gokhan; Vural, Fisun; Gorguc, Merve; Karaoz, Erdal (Humana Press Inc, 2019)Premature ovarian insufficiency (POI), a fertility disorder affecting women under 40years of age, is characterized by early loss of ovarian function. This study was aimed to maintain ovarian function in POI animal models ... -
Efficacy of stem cell therapy in ambulatory and nonambulatory children with Duchenne muscular dystrophy - Phase I-II
Dai, Alper; Baspinar, Osman; Yesilyurt, Ahmet; Sun Gungorurler, Eda; Aydemir, Cigdem Inci; Oztel, Olga Nehir; Karaoz, Erdal (Dove Medical Press Ltd, 2018)Purpose: Duchenne muscular dystrophy (DMD) is an X-linked recessive pediatric disorder that ultimately leads to progressive muscle degeneration. It has been known that cell-based therapies were used to promote muscle ... -
Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: phase I study
Kabatas, Serdar; Civelek, Erdinç; Savrunlu, Eyüp Can; Kaplan, Necati; Boyalı, Osman; Diren, Furkan; Can, Halil; Genç, Ali; Akkoç, Tunç; Karaoz, Erdal (Baishideng Publishing Group Co, 2021)Background Hypoxic-ischemic encephalopathy (HIE) is one of the leading causes of death and long-term neurological impairment in the pediatric population. Despite a limited number of treatments to cure HIE, stem cell therapies ...
