Browsing by Author "Orouei, Sima"

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Overcoming doxorubicin resistance in cancer: siRNA-loaded nanoarchitectures for cancer gene therapy

Deldar Abad Paskeh, Mahshid; Saebfar, Hamidreza; Mahabady, Mahmood Khaksary; Orouei, Sima; Hushmandi, Kiavash; Zarrabi, Ali (2022)

Gene therapy can be used as a cancer therapy by affecting signaling networks participating in the aggressive behavior of tumors. Small interfering RNA (siRNA) is a genetic tool employed for gene silencing. The siRNA molecules ...
Targeting Nrf2 in ischemia-reperfusion alleviation: From signaling networks to therapeutic targeting

Sadrkhanloo, Mehrdokht; Entezari, Maliheh; Orouei, Sima; Zabolian, Amirhossein; Mirzaie, Amirreza; Maghsoudloo, Amin; Raesi, Rasoul; Asadi, Neda; Hashemi, Mehrdad; Zarrabi, Ali; Khan, Haroon; Mirzaei, Sepideh; Samarghandian, Saeed (Elsevier Inc., 2022)

The nuclear factor erythroid 2-related factor 2 (Nrf2) is a master regulator of redox balance and it responds to various cell stresses that oxidative stress is the most well-known one. The Nrf2 should undergo nuclear ...