Browsing by Author "Sardas, Semra"
Now showing items 1-15 of 15
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Biomonitoring of heavy metal(oid)s in the residents of abandoned mining district in northern cyprus
Kocadal, Kumsal; Alkas, Fehmi Burak; Ulutas, Onur Kenan; Kurt, Mehmet Ali; Battal, Dilek; Sardas, Semra; Etikan, Ilker; Saygi, Sahan (Springer, 2021)Abstract Several heavy metal(oid)s are known mutagens and/or carcinogens. Exposure to these elements can lead to the development of malignancies. Gemikonagi, which is in the western part of Cyprus, was the hometown of ... -
Challenge-comet assay, a functional and genomic biomarker for precision risk assessment and disease prevention among exposed workers
Xu, Jianzhen; Sram, Radim J.; Cebulska-Wasilewska, Antonina; Miloradov, Mirjana, V; Sardas, Semra; Au, William W. (Academic Press Inc Elsevier Science, 2020)Advancements in genomic technologies have ushered application of innovative changes into biomedical sciences and clinical medicine. Consequently, these changes have created enormous opportunities to implement precision ... -
Considerations into pharmacogenomics of COVID-19 pharmacotherapy: hope, hype and reality
Al Taie, Anmar; Buyuk, Ayse Seyma; Sardas, Semra (Academic Press, 2022)COVID-19 medicines, such as molnupiravir are beginning to emerge for public health and clinical practice. On the other hand, drugs display marked variability in their efficacy and safety. Hence, COVID-19 medicines, as with ... -
Digging deeper into precision/personalized medicine: cracking the sugar code, the third alphabet of life, and sociomateriality of the cell
Ozdemir, Vural; Arga, K. Yalcin; Aziz, Ramy K.; Bayram, Mustafa; Conley, Shannon N.; Dandara, Collet; Endrenyi, Laszlo; Fisher, Erik; Garvey, Colin K.; Hekim, Nezih; Kunej, Tanja; Sardas, Semra; Von Schomberg, Rene; Yassin, Aymen S.; Yilmaz, Gurcim; Wang, Wei (Mary Ann Liebert, Inc, 2020)Precision/personalized medicine is a hot topic in health care. Often presented with the motto "the right drug, for the right patient, at the right dose, and the right time," precision medicine is a theory for rational ... -
Drug-associated cardiovascular risks: a retrospective evaluation of withdrawn drugs
Kocadal, Kumsal; Saygi, Sahan; Alkas, Fehmi Burak; Sardas, Semra (Kare Publ, 2019)A considerable number of drugs were withdrawn from the world market in the last decades due to safety reasons. A retrospective review of withdrawals is important in determining the adequacy of regulations regarding the ... -
The hCOMET project: international database comparison of results with the comet assay in human biomonitoring. baseline frequency of DNA damage and effect of main confounders
Milić, Mirta; Ceppi, Marcello; Bruzzone, Marco; Azqueta, A.; Brunborg, Gunnar; Godschalk, Roger W.L.; Koppen, Gudrun F.; Sardas, Semra (Elsevier B.V., 2021)The alkaline comet assay, or single cell gel electrophoresis, is one of the most popular methods for assessing DNA damage in human population. One of the open issues concerning this assay is the identification of those ... -
How does infection with human papillomavirus 16 and 18 impact on dna damage and repair in cervical cells and peripheral blood?
Ozcagli, Eren; Biri, Aydan; Dinc, Bedia; Sardas, Semra (Mary Ann Liebert, Inc, 2018)Human papillomavirus (HPV) infection is one of the most common sexually transmitted diseases worldwide and a prime cause of cervical cancer. The HPV DNA is detected in approximately 80-90% of all cervical cancers, with HPV ... -
It is time to revitalize the Antibiotic Pipeline: Systems ecology can help
Sardas, Semra; Buyuk, Ayse Seyma; Beceren, Ayfer (Mary Ann Liebert, Inc, 2020)Antimicrobials have been known for millennia, but innovative antibiotics are currently in short supply. New antimicrobial discoveries are being threatened by planetary scale loss of biodiversity that has important impacts ... -
The long view on COVID-19 theranostics and oral antivirals: living with endemic disease and lessons from molnupiravir
Al-Taie, Anmar; Denkdemir, Fatma Rana; Büyük, Ayşe Şeyma; Şardaş, Semra (Atypon, 2022)The long view on living with COVID-19 as an endemic disease calls for expanding the planetary health inter-vention toolbox. We will need a battery of vaccines, small molecule oral antiviral drugs, and biomarkers toforecast ... -
Panvigilance: integrating biomarkers in clinical trials for systems pharmacovigilance
Sardas, Semra; Kendirci, Asligul (Mary Ann Liebert, Inc, 2019)Drug safety and pharmacovigilance are rapidly changing with biomarkers and new technologies such as artificial intelligence. However, we need new ideas and application contexts for integration of biomarkers and emerging ... -
Pharmacogenomics for clinical trials of COVID-19 medicines: Why is this important now?
Şardaş, Semra; Özdemir, Vural (OMICS, 2021)Historically, pharmacogenomics has origins in biochemical genetics in the 20th century and astute observations on unusual clinical responses to medicines. Extreme drug response phenotypes observed in the clinic have triggered ... -
Role of DNA repair genes XRCC3 and XRCC1 in predisposition to type 2 diabetes mellitus and diabetic nephropathy
Yeşil-Devecioğlu, Tuğçe; Dayan, Akın; Demirtunç, Refik; Şardaş, Semra (Elsevier Science Bv, 2019)Introduction: Increasing number of experimental and clinical studies suggest a strong relationship between hyperglycemia, oxidative stress, DNA damage and diabetic nephropathy (DN). Also, epidemiologic studies remark an ... -
A scoping systematic assessment for post-marketing abuse drug withdrawal
Al-Taie, Anmar; Büyük, Ayşe Şeyma; Şardaş, Semra (OXFORD UNIV PRESS, 2022)Objectives The aim of this study was to identify the post-marketing withdrawal of medicines due to their adverse drug reactions (ADRs)-related abuse effects and to examine the types of evidence, mechanisms and patterns for ... -
Thanatechnology and the living dead: new concepts in digital transformation and human-computer interaction
Özdemir, Vural; Springer, Simon; Yıldırım, Arif; Biçer, Şehmus; Kendirci, Aslıgül; Şardaş, Semra; Kılıç, Hakan; Hekim, Nezih (MARY ANN LIEBERT, 2021)In a digital society, shall we be the authors of our own experience, not only during our lifetime but also after we die? We ask this question because dying and bereavement have become even harder, and much less private, ... -
To genotype or phenotype for drug and food safety? Exiting the technology echo chambers
Özdemir, Vural; Endrenyi, Laszlo; Hekim, Nezih; Kunej, Tanja; Steuten, Lotte M.; Springer, Simon; Şardaş, Semra; Ergüler, Erol; Bayram, Mustafa (Mary Ann Liebert, Inc, 2018)Scholars throughout history have argued there is nothing more important than understanding and explaining the world that we live in. Both scientists and social scientists share this motivation. Yet, they employ ...
