Browsing by Author "Taslimi, Parham"
Now showing items 1-14 of 14
-
1,3-dipolar cycloaddition reactions of the compound obtaining from cyclopentadiene-PTAD and biological activities of adducts formed selectively
Yavari, Mirali Akbar; Taslimi, Parham; Bayrak, Çetin; Taşkın-Tok, Tuğba; Menzek, Abdullah (Wiley, 2021)After known adduct (4) was synthesized by cycloaddition reaction of cyclopentadiene with 4-phenyl-1,2,4-triazoline-3,5-dione, seven new isoxazoline derivatives were synthesized from reactions of 4 with corresponding oximes ... -
Biology-oriented drug synthesis and evaluation of secnidazole esters as novel enzyme inhibitors
Ansari, Muhammad A.; Saad, Syed M.; Khan, Khalid M.; Salar, Uzma; Taslimi, Parham; Taskin-Tok, Tugba; Saleem, Faiza; Jahangir, Sajid (Wiley, 2021)The identification of novel compounds that can inhibit physiologically and metabolically important drug targets or enzymes has prime importance in medicinal chemistry. With this aim, a range of secnidazole esters 1–30 were ... -
Cytotoxic effect, spectroscopy, DFT, enzyme inhibition, and moleculer docking studies of some novel mesitylaminopropanols: antidiabetic and anticholinergics and anticancer potentials
Khalilov, Ali N.; Tüzün, Burak; Taslimi, Parham; Tas, Ayça; Tunçbilek, Zuhal; Çakmak, Neşe Keklikçioğlu (Elsevier, 2021)β-Amino alcohols (2–4) used in this study were re-synthesized in accordance with our previous study. All compounds were characterized by the combination of NMR, UV–Vis, IR experimental and theoretical spectral data. Then, ... -
Cytotoxicity effects and biochemical investigation of novel tetrakis-phthalocyanines bearing 2-thiocytosine moieties with molecular docking studies
Günsel, Armağan; Yıldırım, Aslı; Taslimi, Parham; Erden, Yavuz; Taşkın-Tok, Tuğba (Elsevier, 2022)In this study, the novel 3-(4-aminopyrimidin-2-ylthio) phthalonitrile (1) as starting material was synthesized and its molecular structure was verified by the experiment of single crystal X-ray diffraction, and it was first ... -
Fatty acid composition, enzyme inhibitory effect, antioxidant and anticancer activity of extract from Saponaria prostrata WILLD. subsp. anatolica HEDGE
Erdogan, Mehmet Kadir; Gecibesler, Ibrahim Halil; Yapar, Yakup; Gundogdu, Ramazan; Kirici, Mahinur; Behcet, Lutfi; Taslimi, Parham (Elsevier, 2021)This study attempts to evaluate the antioxidant, enzyme inhibitory, and anticancer properties as well as fatty acid compositions of endemic Saponaria prostrata WILLD. subsp. anatolica HEDGE. The gas chromatography-mass ... -
Improvement of photochemical and enzyme inhibition properties of new BODIPY compound by conjugation with cisplatin
Can Karanlık, Ceren; Karanlık, Gürkan; Taslimi, Parham; Erdoğmuş, Ali (Elsevier, 2022)In this study, new BODIPY complexes were synthesized, characterized and investigated for their some metabolic enzyme inhibition and photophysicochemical properties. BODIPY central core unit was synthesized by using ... -
In vitro cytotoxic effects, in silico studies, some metabolic enzymes inhibition, and vibrational spectral analysis of novel β-amino alcohol compounds
Tas, Ayca; Tuzun, Burak; Khalilov, Ali N.; Taslimi, Parham; Agbektas, Tugba; Cakmak Keklikcioglu, Nese (Elsevier B.V., 2023)In this study, an efficient single-step method for the preparation of β-amino alcohols (1–3) in aqueous media was applied. The aim was to investigate the cytotoxic activity of Compounds 1, 2 and 3 in neuroblastoma SH-SY5Y ... -
Novel tetrakis-phthalocyanines bearing pyrimidine derivative: crystal XRD analysis, enzyme inhibition, molecular docking, and anticancer effects
Günsel, Armağan; Yazar, Bilge; Taslimi, Parham; Erden, Yavuz; Taşkın-Tok, Tuğba; Pişkin, Hasan (Taylor & Francis Online, 2021)In this study, the novel 4-(4-Aminopyrimidin-2-ylthio) phthalonitrile (1) as starting material was synthesized and its 3D structure was verified by the single crystal X-ray diffraction experiment. Then, its peripherally ... -
Potential thiosemicarbazone-based enzyme inhibitors: assessment of antiproliferative activity, metabolic enzyme inhibition properties, and molecular docking calculations
Yakan, Hasan; Kocyigit, Umit M; Muglu, Halit; Ergul, Mustafa; Erkan, Sultan; Guzel, Emre; Taslimi, Parham; Gulcin, Ilhami (2022)A new series of thiosemicarbazone derivatives (1-11) were prepared from various aldehydes and isocyanates with high yields and practical methods. The structures of these compounds were elucidated by Fourier transform ... -
Quinoline-based promising anticancer and antibacterial agents, and some metabolic enzyme inhibitors
Ökten, Salih; Aydın, Ali; Koçyiğit, Ümit Muhammet; Çakmak, Osman; Erkan, Sultan; Andaç, Ahmet Cenk; Taslimi, Parham; Gülçin, İlhami (Wiley-VCH Verlag, 2020)A series of substituted quinolines was screened for their antiproliferative, cytotoxic, antibacterial activities, DNA/protein binding affinity, and anticholinergic properties by using the 3-(4,5-dimethylthiazol-2-yl)-2,5 ... -
Silver N-heterocyclic carbene complexes bearing fluorinated benzyl group: synthesis, characterization, crystal structure, computational studies, and inhibitory properties against some metabolic enzymes
Bal, Selma; Demirci, Ozlem; Sen, Betul; Taskin Tok, Tugba; Taslimi, Parham; Aktas, Aydin; Gok, Yetkin; Aygun, Muhittin; Gulcin, Ilhami (WILEY, 2021)A series of the silver N-heterocyclic carbene (NHC) complexes have been synthesized from the reactions between benzimidazolium salts bearing fluorinated benzyl group and Ag2O via the deprotonation method. All Ag(I)NHC ... -
Sulfonamide-phosphonate hybrids as new carbonic anhydrase inhibitors: In vitro enzymatic inhibition, molecular modeling, and ADMET prediction
Zareei, Samira; Mohammadi-Khanaposhtani, Maryam; Adib, Mehdi; Mahdavi, Mohammad; Taslimi, Parham (Elsevier B.V., 2023)In the presented work, we report the synthesis of a new series of sulfonamide-phosphonate hybrids 4a-m. These newly synthesized compounds were assessed for their inhibitory effects toward two human carbonic anhydrase ... -
Synthesis and evaluation of novel xanthene-based thiazoles as potential antidiabetic agents
Naseem, Saira; Shafiq, Zahid; Taslimi, Parham; Hussain, Saghir; Taşkın Tok, Tuğba; Kısa, Dursun; Saeed, Aamer; Temirak, Ahmed; Tahir, Muhammad N.; Rauf, Khawar; El-Gokha, Ahmed (WILEY-V C H VERLAG GMBH, 2022)A series of xanthene-based thiazoles was synthesized and characterized by different scpectroscopic methods, i.e. Proton nuclear magnetic resonance (H-1 NMR), carbon nuclear magnetic resonance (C-13 NMR), infrared spectroscopy, ... -
Synthesis, biological activity and docking calculations of bis-naphthoquinone derivatives from Lawsone
Riaz, Muhammad Tariq; Yaqub, Muhammad; Shafiq, Zahid; Ashraf, Abida; Khalid, Muhammad Umar; Taslimi, Parham; Taş, Recep; TÜzÜn, Burak; Gülçın, Ìlhami (Academic Press Inc., 2021)Some metabolic enzyme inhibitors can be used as Multi-target-Directed-Ligands (MTDL) in Medicinal chemistry therefore, synthesis and determination of alternative inhibitors are essential. In this study, novel bis-napthoquinone ...
