Browsing by Author "Ulukaya, Engin"
Now showing items 1-20 of 74
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Anticancer potential of albumin bound wnt/beta-catenin pathway inhibitor niclosamide in breast cancer cells
Ari, Ferda; Erkisa, Merve; Pekel, Gonca; Erturk, Elif; Buyukkoroglu, Gulay; Ulukaya, Engin (WILEY, 2021)Albumin-based nanoparticle transport systems (nab-technology) are a new strategy in cancer treatment and we aimed to increase the effectiveness of Niclosamide using this technology. Niclosamide was bound with bovine serum ... -
Assessment of oxidative stress effects in serum determined by FT-IR spectroscopy in cholangiocarcinoma patients
Bulut, Huri; Tarhan, Nevzat; Buyuk, Melek; Serin, Kurşat Rahmi; Ulukaya, Engin; Depciuch, Joanna; Parlinska-Wojtan, Magdalena; Guleken, Zozan (AMG Transcend Association, 2023)Cholangiocarcinoma (CCA) is a heterogeneous malignant tumor containing intrahepatic and extrahepatic bile ducts and gallbladder carcinoma. Mostly diagnosed at an advanced stage with a <5% cure chance. Early-stage diagnosis ... -
Baicalein ve thymoquinone kombinasyounun akciğer kanseri hücre hattı üzerindeki sitotoksit ve apoptotik etkilerinin araştırılması
Shokouhy Ardebili, Sonia (İstinye Üniversitesi / Sağlık Bilimleri Enstitüsü, 2021)Akciğer kanseri dünya çapında önde gelen ölüm nedenidir. Kemoterapi tedavi sonrası hücrelerde meydana gelen direnç, kanser ölümlerin çoğalmasının nedenidir. Bu nedenle akciğer kanseri tedavisinde yönelik yeni ilaç ve ... -
Bioassay-guided isolation of cytotoxic compounds from chrysophthalmum montanum (DC.) boiss
Ayaz, Fatma; Kucukboyaci, Nurgun; Goren, Nezhun; Calis, Ihsan; Aydinlik, Seyma; Ulukaya, Engin; Duman, Hayri; Choudhary, Muhammad Iqbal (Pergamon-Elsevier Science Ltd, 2019)Bioassay-guided isolation of the 80% methanol extract of the aerial parts of Chrysophthalmum montanum (DC.) Boiss. (Asteraceae) led to the isolation of four known guaianolide-type sesquiterpene lactones, 6 alpha-acetoxy-4 ... -
Cancer stem cells : root of the evil
Erkisa Genel, Merve; Karakas Zeybek, Didem; Ulukaya, Engin (Begell House Inc., 2019)Cancer stem cells (CSCs) have been one of the most attractive research areas over the last two decades due to their important roles in aggressive tumor behaviors. Although CSCs are usually a small subpopulation of tumors ... -
Chloroquine used in combination with chemotherapy synergistically suppresses growth and angiogenesis in vitro and in vivo
Gurel-Gurevin, Ebru; Kiyan, Hulya Tuba; Esener, Osman Behzat Burak; Aydinlik, Seyma; Uvez, Ayca; Ulukaya, Engin; Dimas, Konstantinos; Armutak, Elif Ilkay (Int Inst Anticancer Research, 2018)Background: The inhibition of autophagy using pharmacological inhibitors such as chloroquine may be an effective strategy to overcome chemotherapy or resistance to anti-angiogenic therapy. Materials and Methods: The cytotoxic ... -
Combination of histone deacetylase inhibitor with Cu(II) 5,5- diethylbarbiturate complex induces apoptosis in breast cancer stem cells: a promising novel approach
Background: Cancer stem cells (CSC) are subpopulation within the tumor that acts a part in the initiation, progression, recurrence, resistance to drugs and metastasis of cancer. It is well known that epigenetic changes ... -
Computer-aided prediction and cytotoxicity evaluation of dithiocarbamates of 9,10-anthracenedione as new anticancer agents
Stasevych, M.; Zvarych, V.; Lunin, V.; Deniz, N. G.; Gokmen, Z.; Akgun, O.; Ulukaya, Engin; Poroikov, V.; Gloriozova, T.; Novikov, V. (Taylor & Francis Ltd, 2017)Anticancer activity as an associated action for a series of dithiocarbamates of 9,10-anthracenedione was predicted using the PASS computer program and analysed with PharmaExpert software. The predicted cytotoxic activity ... -
Cytotoxic and apoptotic effects of the combination of palladium (II) 5,5-diethylbarbiturate complex with bis(2-pyridylmethyl)amine and curcumin on non small lung cancer cell lines
Tunc, Duygu; Dere, Egemen; Karakas, Didem; Cevatemre, Buse; Yilmaz, Veysel Turan; Ulukaya, Engin (Pergamon-Elsevier Science Ltd, 2017)Metal-based chemotherapeutics such as cisplatin are widely used treatment of lung cancer which is the major cause of cancer-related mortality worldwide. Recent studies demonstrated that novel metal-based compounds have ... -
Cytotoxic and genotoxic effects of an endemic plant of Turkey salvia kronenburgii on breast cancer cell lines
Cebi, Aysegul; Akgun, Egemen; Celikler, Serap; Firat, Mehmet; Ozel, Mustafa Zafer; Ulukaya, Engin; Ari, Ferda (Wolters Kluwer Medknow Publications, 2019)Context: The natural products derived from plants are the important sources that can be used for breast cancer treatment. Salvia species and their derived products were recommended as potential antitumor substances. Aim: ... -
Cytotoxic effect of conyza canadensis (L.) cronquist on human lung cancer cell lines
Ayaz, Fatma; Sarimahmut, Mehmet; Kucukboyaci, Nurgun; Ulukaya, Engin (Turkish Pharmacists Assoc, 2016)Asteraceae family plants are receiving great attention because they have potential anticancer activity. Therefore, in this study, the cytotoxic effect of Conyza canadensis (L.) Cronquist (Asteraceae) were tested against ... -
Cytotoxic platinum(II) complexes derived from saccharinate and phosphine ligands: synthesis, structures, DNA cleavage, and oxidative stress-induced apoptosis
Icsel, Ceyda; Yilmaz, Veysel T.; Cevatemre, Buse; Aygun, Muhittin; Ulukaya, Engin (Springer, 2020)A series of the structurally related platinum(II) saccharinate (sac) complexes with alkylphenylphosphines, namely cis-[Pt(sac)(2)(PPh2Me)(2)]center dot DMSO (1), cis-[Pt(sac)(2)(PPhMe2)(2)] (2), cis-[Pt(sac)(2)(PPh2Et)(2)] ... -
Development of a cysteine responsive chlorinated hemicyanine for image-guided dual phototherapy
Savani, Samira; Onbaslİ, Kubra; Gunduz, Eren; Aydındogan, Eda; Erkısa, Merve; Muti, Abdullah; Khan, Minahil; Sennaroglu, Alphan; Ulukaya, Engin; Yagci Acar, Havva; Kolemen, Safacan (2022)A cysteine (Cys) activatable chlorinated hemicyanine (Cl-Cys) was introduced as a tumour selective image-guided dual phototherapy agent. Cl-Cys exhibited a significant turn on response in its near-IR emission signal and ... -
Development of near-infrared region luminescent N-acetyl-L-cysteine-coated Ag2S quantum dots with differential therapeutic effect
Buz, Pelin Turhan; Duman, Fatma Demir; Erkisa Genel, Merve; Demirci, Gozde; Ari, Ferda; Ulukaya, Engin; Acar, Havva Yagci (Future Medicine Ltd, 2019)Aim: N-acetyl-L-cysteine (NAC) is a free radical scavenger. We developed NAC-coated Ag2S (NAC-Ag2S) quantum dot (QD) as an optical imaging and therapeutic agent. Materials & methods: QDs were synthesized in water. Their ... -
Differential of cholangiocarcinoma disease using Raman spectroscopy combined with multivariate analysis
Depciuch, Joanna; Parlinska-Wojtan, Magdalena; Serin, Kursat Rahmi; Bulut, Huri; Ulukaya, Engin; Tarhan, Nevzat; Guleken, Zozan (2022)Cholangiocarcinoma (CCA) is a type of cancer, which 5-year survival is lower than 20 %, and which is detected mostly in advanced stage of the disease. Unfortunately, there are no diagnostic tools, which could show changes ... -
DNA damage response inhibitors in cholangiocarcinoma: current progress and perspectives
Anichini, Giulia; Ulukaya, Engin; Marra, Fabio; Raggi, Chiara; Geyik, Öykü Gönül (PubMed, 2022)Cholangiocarcinoma (CCA) is a poorly treatable type of cancer and its incidence is dramatically increasing. The lack of understanding of the biology of this tumor has slowed down the identification of novel targets and the ... -
Dznep ve spironolakton kombinasyonunun akciğer kanseri hücre soyunda sitotoksik/apoptotik etkilerinin araştırılması
Kaymaz, Selin (İstinye Üniversitesi / Sağlık Bilimleri Enstitüsü, 2021)Akciğer kanseri, günümüzde teşhisi konulan tüm kanserlerin büyük kısmını oluşturmaktadır ve kanser ölümlerinin önde gelen nedeni olmaya devam etmektedir. Akciğer kanserlerinin tedavisi için ameliyat, radyoterapi, kemoterapi, ... -
The effect of NOTCH, IL-1 and LEPTIN (NILCO) inhibition in xenograft colorectal cancer
Ozyurt, R.; Erkasap, N.; Ozkurt, M.; Erkasap, S.; Ulukaya, Engin; Dimas, K. (Wiley, 2019)Questions: Studies in various cancer tissues have shown that Notch, IL-1 and leptin interaction (NILCO) play a role in the proliferation, migration and expression of proangogenic molecules. It has been suggested that ... -
Effects of exosomes on major pathways promote tumor formation and progression
Kose, Mehmet Emin; Aydin, Beste; Geyik, Caner; Gonul Geyik, Oyku; Ulukaya, Engin (Bentham Science, 2021)Exosomal vesicles enclose and carry a broad range of biological molecules, such as nucleic acids, lipids, and proteins, and transfer them between cells. In cancer, cells being mentioned could be neighbors in the same tumor ...
